Dongkwang Cimetidine Injection

Adult administration

1) Intravenous injection Administer 200 mg of cimetidine intravenously every 4 to 6 hours. Do not exceed 2 g per day. 2) Infusion intravenous injection Administer 200 mg of this drug through intravenous infusion over 2 hours every 4 to 6 hours. Do not exceed a maximum infusion rate of 150 mg per hour or 2 mg per kg body weight per hour. When infusing continuously, the average infusion rate should not exceed 75 mg per hour over a 24-hour period, and the maximum daily infusion amount should not exceed 2 g.

Child administration

Divided intravenous administration of 20 to 40 mg per kg of body weight per day. Adjust appropriately according to age and symptoms.

This medication is provided in glass ampoule form, so it must be carefully cut to avoid glass fragments mixing in before use. Extreme caution is especially needed when administering it to children and the elderly. Patients with a history of allergy or hypersensitivity reactions to this drug, as well as those taking dofetilide, should not be administered this medication. The use of dofetilide together may increase the risk of cardiac arrhythmias. Patients with impaired kidney or liver function, those with a drug allergy history, the elderly, children under 19 years old, and patients undergoing hemodialysis may require dose adjustment or changes in administration intervals, and because gastric cancer symptoms may be masked, it is necessary to verify malignancy before administration. Patients with peptic ulcers infected by Helicobacter pylori should also undergo bacterial eradication therapy. This drug can cause various side effects, including decreased blood cell counts, liver dysfunction, renal impairment, allergic reactions, endocrine dysfunction, gastrointestinal symptoms, neurological symptoms, cardiovascular anomalies, skin reactions; therefore, if any abnormal symptoms occur, medical personnel should be notified immediately. During treatment, the course of the disease should be monitored closely, and if there is no effect, a change to another treatment method should be considered. Additionally, blood, liver, and kidney function tests should be conducted regularly to check for abnormalities. The elderly, those with chronic illnesses, and immunocompromised patients may have an increased risk of pneumonia when taking this medication; hence caution is advised. There may also be interactions with other medications, such as coumarin anticoagulants, so administration should be discussed with health professionals. Women who are pregnant or may become pregnant should carefully consider the administration of this medication as its effects on the fetus are not fully understood. In nursing mothers, this drug may be excreted in breast milk, so it is advisable to discontinue breastfeeding. In children, safety has not been sufficiently confirmed, so it should only be used when the therapeutic benefits outweigh the risks. In cases of overdose, serious side effects such as respiratory depression may occur, necessitating immediate emergency care. When administered as an injection, there is a risk of arrhythmias or hypotension resulting from rapid intravenous injection, so slow injection is safer. Finally, this medication should be stored out of reach of children, and transferring it to another container should be avoided as it may lead to accidents and degradation of quality.

Serious side effects

Reaction including glass fragment contamination, general malaise, weakness, subcutaneous hemorrhage, mucosal hemorrhage, abnormal blood tests due to fever, immune hemolytic anemia, jaundice, renal impairment, fever, abnormal renal function tests, shock, anaphylactic reactions, generalized rash, respiratory distress, hypersensitivity vasculitis, rash, altered consciousness, seizures, reversible confusional state, psychosis, hallucinations, loss of orientation, skin and mucous membrane syndrome, Stevens-Johnson syndrome, toxic epidermal necrolysis.

Mild side effects

• Leukopenia
• neutropenia
• agranulocytosis
• thrombocytopenia
• pancytopenia
• aplastic anemia
• hepatitis
• increased AST
• ALT
• liver fibrosis

This medication should be stored in a sealed container that does not come into contact with air, preferably at room temperature between 1 and 30 degrees Celsius. Storing it this way will maintain the effectiveness of the drug and prevent degradation.

Appearance

A colorless or pale yellow transparent solution in a colorless transparent ampoule injection.

Package unit

50 ampoules/box [(2 milliliters/ampoule)]