Cimetidine Tablet (Cimetidine)

Key information summary

Efficacy & effects

This medication is used to treat various gastrointestinal diseases, such as gastric and duodenal ulcers, gastroesophageal reflux disease, recurrent ulcers, anastomotic ulcers, and Zollinger-Ellison syndrome. It also helps improve symptoms like erosion, bleeding, redness, and swelling, which are mucosal lesions that occur during the acute exacerbations of acute and chronic gastritis. This drug helps to effectively manage digestive health by protecting the gastric mucosa and reducing inflammation. If you seek relief from gastrointestinal symptoms, this medication is suitable. Overall, it is used to enhance gastrointestinal health and aid in the treatment of diseases.

Dosage

As cimetidine, it can be taken as 400 mg orally twice a day (in the morning and at bedtime) or once a day as 800 mg at bedtime. Additionally, 300 mg can be taken orally four times a day (after meals, at bedtime). The dose may be increased to a maximum of 1.6 g as 400 mg four times a day (after meals, at bedtime). In cases of acute gastric and chronic gastritis exacerbations, 200 mg can be taken twice a day or 400 mg once a day.

Precautions

When using this drug in ampoule injection form, there is a risk of glass fragments entering, so great care must be taken when cutting the container. This should be handled even more cautiously when used in children or elderly patients. This drug should not be administered to patients who have had allergic reactions or hypersensitivity to cimetidine or other components. Additionally, it should not be used in patients taking dofetilide as it may increase the risk of cardiac arrhythmias. It contains lactose, so it should not be administered to patients with lactose intolerance or related genetic disorders. Patients with kidney or liver function issues, a history of drug allergies, elderly patients, children under 19 years of age, and patients undergoing hemodialysis should use caution when using this medication. Particularly, patients with impaired kidney function may require dose adjustment due to increased drug concentration. During treatment, blood tests may show reduced white blood cell or platelet counts; if symptoms such as fatigue, bleeding, or fever occur, the hospital should be notified immediately. Rarely, symptoms of liver or kidney dysfunction may appear, so careful observation is required. Hypersensitivity reactions can occur, such as shock, difficulty breathing, or skin rashes, and if these symptoms occur, administration should be stopped immediately. Hormonal side effects such as gynecomastia, excessive milk secretion, and erectile dysfunction have also been reported. Gastrointestinal symptoms like abdominal distension, diarrhea, constipation, as well as neurological symptoms like headache, dizziness, drowsiness, and mental confusion may occur, though rarely. Elderly patients or those with weakened kidney function are more prone to symptoms of mental confusion, so caution is advised. Cardiac side effects like bradycardia, tachycardia, and palpitations are rarely reported. Serious systemic skin reactions may occur very rarely; therefore, skin condition should be closely monitored. This medication interacts with many other drugs, so when taken with warfarin, midazolam, diazepam, theophylline, etc., dose adjustment and monitoring of blood concentration are necessary. Women who are pregnant or breastfeeding should use this medication only if absolutely necessary under a doctor's discretion, and it is advisable to stop breastfeeding during treatment. The safety in children has not been sufficiently confirmed; therefore, it should be administered cautiously only when absolutely necessary. Elderly patients may have prolonged drug retention in the body due to decreased kidney function, so doses should be reduced or intervals extended. In case of overdose, respiratory depression may occur, requiring appropriate emergency measures like ventilator support or gastric lavage. When administered as an injectable form, rapid intravenous injection may lead to arrhythmias or hypotension; thus, it should be given slowly. This medication should be stored in a secure place out of the reach of children, and transferring it to another container may lead to quality degradation or accident risks, which should be avoided.

Side effects

Leukopenia, granulocytopenia, agranulocytosis, thrombocytopenia, panleukopenia, aplastic anemia, autoimmune hemolytic anemia, jaundice, hepatitis, elevated AST, ALT, liver fibrosis, interstitial seizures, acute renal failure, interstitial nephritis, urinary retention, elevated BUN, shock, anaphylactoid reactions, hypersensitivity vasculitis, headache, seizures, altered consciousness, confusion state, sinus bradycardia, tachycardia, palpitations, atrioventricular block, Stevens-Johnson syndrome.

Alternatives / Same-ingredient medications

• 

  International Cimetidine Tablet

  Same ingredient
• Tagamet Injection (Cimetidine)

  Same ingredient
• 

  Cignatin Tablet (Cimetidine)

  Same ingredient
• 

  Cimetidine 300mg Tablets (Cimetidine)

  Same ingredient

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