Daparon Duo Extended Release Tablet 5/500 mg

Adult dose

This medication is generally administered once daily with the evening meal. The maximum dosage is once daily of dapagliflozin 10 mg/extended-release metformin 2000 mg. The recommended starting dosage for initial therapy is 1 tablet of 5 mg/500 mg or 10 mg/500 mg once daily. To minimize gastrointestinal side effects of metformin, dosage should be adjusted gradually. For patients receiving treatment with metformin, dapagliflozin

This drug is a combination agent used for the treatment of type 2 diabetes. When taking this medication, there is a very rare but serious metabolic complication known as lactic acidosis that may occur, so caution is advised. The risk of lactic acidosis may increase in cases of impaired kidney function, severe infection, dehydration, or heart problems. Additionally, this medication may cause hypoglycemia when taken with insulin or sulfonylureas, so careful monitoring of blood glucose changes is necessary. It should not be administered to patients with moderate to severe renal impairment or those with dehydration, severe infections, acute myocardial infarction, septicemia, etc. This medication is also prohibited for use in patients undergoing surgery, those with severe infections, heart failure patients, and women who are pregnant or breastfeeding. In elderly patients or those with reduced kidney function, regular assessment of fluid volume status and kidney function is necessary, and dose adjustment is needed to reduce the risk of hypotension or kidney damage. This drug can increase urination, potentially causing reduced fluid volume and hypotension; therefore, particular caution is necessary for elderly patients or those taking antihypertensive medications. While taking this medication, there may be an increased risk of genital and urinary tract infections; if infection symptoms appear, consult healthcare professionals immediately. This medication may cause vitamin B12 deficiency; therefore, monitoring through blood tests is necessary for long-term use. Excessive alcohol consumption may increase the risk of lactic acidosis, so it is advisable to avoid alcohol while taking this medication. During pregnancy or breastfeeding, this medication should not be used, and it should be discontinued immediately if pregnancy is confirmed. The risk of hypoglycemia may increase when this medication is used in combination with other diabetes treatments, thus dosage adjustments are essential. In the case of overdose, immediate medical attention is required, and dialysis may be beneficial if needed. Caution is also necessary while driving or operating machinery, as dizziness may occur during treatment. Keep the medication out of reach of children and store it in its original container to prevent degradation of quality.

Serious side effects

Severe lactic acidosis, severe hypoglycemia, severe allergic reactions (hives, severe swelling, chest tightness, difficulty breathing, cold sweat, pallor), severe skin adverse reactions (severe rash with fever, blisters, skin peeling, pain in mouth/eyes mucosa), respiratory issues (shortness of breath or difficulty breathing, asthma attacks, cough with fever associated respiratory issues), liver abnormalities (skin or eye

Mild side effects

Vulvovaginitis, balanitis and related genital infections, urinary tract infections, fungal infections, hypoglycemia (when used with sulfonylureas or insulin), decreased fluid volume (including dehydration, hypovolemia, hypotension), thirst, dizziness, constipation, dry mouth, back pain, dysuria, polyuria, nocturia, vulvar pruritus, genital pruritus, increased hematocrit, initial decrease in renal creatinine clearance, dyslipidemia, initial blood concentration

This medication should be stored in a tightly sealed container to protect it from air and moisture, at room temperature between 1 and 30 degrees Celsius. Storing it this way will help maintain its effectiveness over time.

Appearance

Orange biconvex rectangular extended release film-coated tablet

Package unit

30 tablets/bottle