Pfizer Methotrexate Injection 1 g

Key information summary

Efficacy & effects

The tablet form of the medication is used for the relief of symptoms of leukemia, choriocarcinoma (choriocarcinoma, destructive hydatidiform mole, hydatidiform mole), rheumatic arthritis, and severe refractory psoriasis that is ineffective with other medications. The injection form is extensively used for various solid tumors and choriocarcinoma, such as acute leukemia, non-Hodgkin lymphoma, sarcoma, breast cancer, lung cancer, head and neck cancer, and bladder cancer, and is also used for severe refractory psoriasis.

Dosage

1. Leukemia: Administer methotrexate 5–10 mg orally once daily for 3–6 days per week. 2. Choriocarcinoma: Administer 10–30 mg orally daily. Cycle for 5 days followed by a 7–12 days break before repeating. 3. Rheumatoid arthritis: Administer 7.5–20 mg orally once a week or divide into 3 doses at 12-hour intervals. The total weekly dosage should not exceed 20 mg.

Precautions

This medication should be taken once a week when treating rheumatoid arthritis or psoriasis, and dosage errors can lead to serious side effects, so caution is advised. When used together with certain other medications, the risk of side effects may increase, so it should be administered under medical supervision. Particularly, patients with poor kidney or liver function, those with blood disorders, pregnant women or women who may become pregnant, and nursing mothers should not use this medication. Caution should be exercised in administering to those with diarrhea, stomatitis, gastric ulcers, infections, the elderly, and children, and any unusual symptoms should be reported to medical personnel immediately. This medication can cause serious allergic reactions, gastrointestinal bleeding, pulmonary diseases, neurological disorders, blood abnormalities, and liver and kidney damage, so the patient's condition should be monitored regularly. Additionally, this medication can affect reproductive function, so pregnancy should be avoided during and after treatment for a certain period of time, and men are also advised to use contraception. There is a high possibility of interactions with other medications during treatment, so all medications being taken should be disclosed to medical personnel and regular examinations should be conducted. In case of overdose, medical personnel should be notified immediately, and appropriate detoxification treatment should be undertaken. This medication should only be used in a professional medical environment.

Side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, low blood pressure, coldness, anaphylactoid symptoms, hemorrhagic colitis, necrotizing colitis, blisters, skin peeling, oral/ocular mucosal pain, alveolar hemorrhage, pulmonary fibrosis, interstitial pneumonia, fever, cough, respiratory distress, skin and mucosal syndrome (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell syndrome), severe infections, pneumonia, sepsis, headache (severe headache, thunderclap headache)

Alternatives / Same-ingredient medications

• MTX Injection (Methotrexate)

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• 

  Yuhan Methotrexate Tablets

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• Yuhan Methotrexate Injection 25 mg/mL

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• Pfizer Methotrexate Injection 5 g

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