Yuhan Methotrexate Tablets

Adult dosage

1. Leukemia: Administer 5～10 mg of methotrexate orally per day for 3～6 days per week. 2. Trophoblastic disease: Administer 10～30 mg orally per day for 5 days as one treatment cycle, then repeat after a 7～12-day drug-free interval. 3. Rheumatoid arthritis: One week before treatment, administer a single 5～10 mg test dose orally and assess for adverse reactions. Then administer 7.5～20 mg orally once weekly, or divide the dose into 3 doses administered orally at 12-hour intervals. 4. Psoriasis: One week before treatment, administer a single 5～10 mg test dose orally and assess for adverse reactions. Then administer 7.5～20 mg orally once weekly, or divide the dose into 3 doses administered orally at 12-hour intervals. For the injectable product—psoriasis: Administer 10～25 mg once weekly orally or by intravenous or intramuscular injection, adjusting the dose according to the patient's response. For the injectable product—breast cancer, lung cancer, head and neck cancer, bladder cancer, osteosarcoma, and non-Hodgkin lymphoma: The dose administered by intravenous injection or infusion varies according to the type of cancer.

Children's dosage

Leukemia: Administer 1.25～2.5 mg orally per day for 3～6 days per week. For the injectable product—meningeal leukemia in children: Administer 12～15 mg/㎡ by intrathecal injection at 1-week intervals. For the injectable product—trophoblastic disease: Administer 10～30 mg/㎡ by intramuscular injection daily for 5 days, then repeat after a 7～12-day drug-free interval.

This drug is used to treat rheumatoid arthritis or psoriasis and should only be taken once a week. Strict adherence to the dosing regimen is crucial, as failure to comply may lead to serious side effects. Combination therapy with this drug and other anticancer agents is risky and must be managed under the supervision of a physician. Adequate medical facilities and an experienced physician are also necessary. Patients with allergies to any component of this drug, impaired kidney or liver functions, patients with pleural effusion or ascites, certain blood disorders, immunodeficiency, alcohol dependence, women who are pregnant or potentially pregnant, breastfeeding mothers, and patients with specific genetic disorders should not use this drug. Patients with diarrhea, stomatitis, gastric ulcers, blood abnormalities, bone marrow suppression, varicella infections, infections, mental disorders, children, and the elderly should use this medication cautiously. This drug may rarely cause severe allergic reactions, such as shock or anaphylaxis, and any unusual symptoms during treatment should prompt immediate discontinuation and hospital consultation. Gastrointestinal side effects may include hemorrhagic enteritis, nausea, vomiting, stomatitis, abdominal pain, diarrhea, and pancreatitis should also be monitored. Respiratory side effects may manifest as pneumonia or pulmonary fibrosis; thus, immediate examination and treatment are required if fever, cough, or shortness of breath occur. Neurological effects may include headache, drowsiness, blurred vision, and seizures. Reproductive system side effects such as infertility, menstrual irregularities, and fetal malformations have been reported. Hematologic side effects may include anemia, leukopenia, and thrombocytopenia indicating bone marrow suppression, necessitating regular blood testing. The drug may affect liver and kidney function, so regular monitoring and observation of conditions are critical, and use should be discontinued if abnormalities are found. Skin reactions such as severe rashes, skin desquamation, and photosensitivity reactions may occur and should be carefully observed. The risk of infections may increase, and treatment should be sought immediately if symptoms of infection arise. Bone health issues, such as osteoporosis, may also develop, thus regular assessments during long-term use are necessary. This drug can interact with various medications, so it is crucial to consult a doctor or pharmacist if taking other medications concurrently. Women who are pregnant or may become pregnant must avoid this medication, as it poses serious risks to the fetus; it should not be administered while breastfeeding as well. Children and the elderly may be more susceptible to side effects of this medication, so caution is warranted during administration. In case of overdose, seek immediate medical attention for appropriate detoxification treatment, and keep this medication out of the reach of children.

• Shock
• anaphylactic symptoms
• hemorrhagic colitis
• necrotizing colitis
• abdominal pain
• diarrhea
• nausea
• vomiting
• stomatitis
• loss of appetite

This medication should be stored in a tightly sealed container to protect it from air and moisture. The storage temperature should be maintained between 1 to 30 degrees Celsius at room temperature.

Appearance

This medication is a yellow, round tablet.

Package unit

100 tablets/PTP (10 tablets/PTP x 10)