Pfizer Methotrexate Injection 5 g

Key information summary

Efficacy & effects

This medication is used for the treatment of leukemia, rheumatoid arthritis, and severe refractory psoriasis. It also assists in relieving symptoms of trophoblastic diseases, particularly trophoblastic cancer, destructive molar pregnancy, and molar pregnancy. In injection form, it is utilized for various solid tumors such as acute leukemia, non-Hodgkin lymphoma, several sarcomas, and breast cancer, lung cancer, head and neck cancer, and bladder cancer. It is effectively used for various cancers and intractable diseases, contributing to patient condition improvement.

Dosage

1. Leukemia: Administer 5 to 10 mg orally for 3 to 6 days a week. 2. Trophoblastic disease: Administer 10 to 30 mg orally daily, with 5 days on and a 7 to 12 day rest period before repeating. 3. Rheumatoid arthritis: Administer a test dose of 5 to 10 mg orally one week prior to treatment. Administer 7.5 to 20 mg orally once a week or 2 times 12 hours apart.

Precautions

This medication should only be taken once a week when treating rheumatoid arthritis or psoriasis, and serious side effects may occur due to dosing errors; therefore, strict adherence to the prescribed dosage and guidelines is essential. When using this medication in conjunction with other drugs, it must be under medical supervision, particularly when used with proton pump inhibitors, as this may increase blood concentration leading to toxicity. Patients with impaired kidney or liver function, those with blood disorders, pregnant women or those who may become pregnant, nursing mothers, and individuals taking certain medications should not use this medication. Patients with diarrhea, stomatitis, gastric ulcers, infections, children, and the elderly should use this medication with extra caution, and if abnormal symptoms occur, they should immediately consult a physician. This medication can cause various side effects, including severe gastrointestinal adverse reactions, respiratory diseases, neuropsychiatric symptoms, blood and liver dysfunctions, kidney problems, skin adverse reactions, and infections, so the patient’s condition must be monitored frequently, and administration should be terminated if necessary. Especially during pregnancy, there can be severe impacts on the fetus, so women who are pregnant or planning to become pregnant should not take this medication, and male patients should avoid pregnancy for at least 6 months during and after treatment. Regular blood tests, liver and kidney function tests are required during administration of this medication, and immediate action should be taken if any abnormal signs are detected. In case of overdose, immediate administration of the antidote levoleucovorin is necessary, along with adequate hydration and urine alkalinization to reduce strain on the kidneys, and strict medical supervision is essential. This medication has many interactions with other drugs, so it is imperative to consult healthcare providers, especially when used in combination with non-steroidal anti-inflammatory drugs, aspirin, antibiotics, etc.

Side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweats, pallor, severe rash with high fever, blistering, skin peeling, oral/ocular mucosal pain, pulmonary hemorrhage, pulmonary fibrosis, liver abnormalities (jaundice), profound lethargy, sudden and severe headache, thunderclap headache, seizures, mental confusion, visual disturbances, paralysis, significantly decreased urine output, severe systemic swelling and increased blood pressure, anaphylaxis

Alternatives / Same-ingredient medications

• MTX Injection (Methotrexate)

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• 

  Yuhan Methotrexate Tablets

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• Yuhan Methotrexate Injection 25 mg/mL

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• Pfizer Methotrexate Injection 1 g

  Same ingredient

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