
Key information summary
Efficacy & effects
This medication is effective for inflammatory diseases of the joints and muscles, such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. It is also used to treat tendon inflammation (tendinitis), acute gout, and dysmenorrhea. Additionally, it helps with bursitis, muscle and ligament injuries, lower back pain, postoperative pain relief, as well as migraine and pain relief after tooth extraction. Overall, it is widely utilized in the treatment of various pain and inflammatory disorders.
Dosage
1. Rheumatoid arthritis, osteoarthritis, ankylosing spondylitis: Administer 275-550 mg of naproxen sodium orally twice daily (every 12 hours). 2. Acute gout: Initial dose of 825 mg orally, followed by 275 mg orally every 8 hours until the attack subsides. 3. Skeletal muscle disorders, postoperative pain, pain after tooth extraction, dysmenorrhea, tendinitis, bursitis: Initial dose of 550 mg.
Precautions
Patients who regularly consume more than three alcoholic beverages daily should discuss this medication with a doctor or pharmacist, as taking it with alcohol may increase the risk of gastrointestinal bleeding. This medication may increase the risk of cardiovascular diseases. Caution should be exercised by those with cardiovascular conditions or risk factors, as serious vascular issues such as myocardial infarction or stroke may occur. If cardiovascular symptoms develop during treatment, contact a healthcare professional immediately. This medication can also cause serious gastrointestinal issues such as gastrointestinal bleeding, ulcers, and perforations. The risk may be higher for the elderly or those taking it for extended periods, so immediate medical attention is required for any gastrointestinal symptoms. Individuals with a history of peptic ulcers, severe blood disorders, liver dysfunction, heart failure, kidney disorders, hypertension, etc., should not take this medication. Additionally, it should not be used by those with allergies to any components of this medication or those who have had hypersensitivity reactions to non-steroidal anti-inflammatory drugs like aspirin. Patients with a history of peptic ulcers, hematological disorders, liver dysfunction, kidney dysfunction, hypertension, or asthma should use this medication cautiously and consult a healthcare professional if any unusual symptoms arise. Side effects such as allergic reactions, gastrointestinal bleeding, blood disorders, liver or kidney dysfunction, skin rashes, headaches, dizziness, and auditory and visual disturbances may occur with this medication. If any of these symptoms appear, discontinue use immediately and consult a doctor. This medication should be used at the lowest possible dose for the shortest duration to reduce the risk of side effects, and regular blood tests along with liver and kidney function tests should be conducted during prolonged use. Patients with abnormalities in cardiovascular, gastrointestinal, liver, or kidney functions should take this medication under close observation. Taking this medication with other non-steroidal anti-inflammatory drugs may increase the risk of side effects, so it is advisable not to combine them. Furthermore, there may be interactions with certain blood pressure medications, diuretics, anticoagulants, or chemotherapeutic agents, so inform healthcare professionals of any current medications.
Side effects
Hives, severe swelling, chest tightness, difficulty breathing, cold sweat → severe allergic reaction Severe rash with high fever, blisters, skin peeling, pain in oral/ocular mucosa → severe skin abnormal reaction Shortness of breath or difficulty breathing, asthma attack, cough accompanied by fever → respiratory issues Skin or eyes turning yellow (jaundice), profound lethargy → liver issues (jaundice) Sudden and severe headache
Interactions
Do not take this medication with other non-steroidal anti-inflammatory drugs and naproxen derivatives. Use caution when taking with hydantoins, sulfonamides, sulfonylurea hypoglycemic agents, propranolol and other beta-blockers, ACE inhibitors, loop and thiazide diuretics, probenecid, aspirin, lithium, methotrexate, coumarin anticoagulants, zidovudine, and quinolone antibiotics; consult with a doctor or pharmacist.



