Zynal Tablet (Naproxen Sodium)

Adult dose

1. Rheumatoid arthritis, osteoarthritis, ankylosing spondylitis: Administer 275-550mg of naproxen sodium orally twice a day (every 12 hours). 2. Acute gout: Administer an initial dose of 825mg orally and continue with 275mg every 8 hours until the attack ceases. 3. Skeletal muscle disorders, postoperative pain, pain after tooth extraction, dysmenorrhea, tendinitis, bursitis: Administer an initial dose of 550mg orally, then give 275mg every 6-8 hours. Do not exceed a total daily dose of 1350mg. 4. Migraine: Administer an initial dose of 825mg orally. If necessary, an additional 275-550mg may be given up to a total daily dose of 1350mg, with the second dose given 30 minutes after the initial dose. Adjust dosage as appropriate according to age and symptoms.

This medication should be discussed with a doctor or pharmacist if taken by individuals who regularly consume three or more alcoholic beverages daily, as this poses a risk of gastrointestinal bleeding. Patients with cardiovascular diseases or risk factors should be cautious, as taking this medication may increase the likelihood of cardiac issues such as myocardial infarction or stroke. This medication can cause serious adverse reactions such as gastrointestinal bleeding, ulcers, or perforation, and the risk is especially greater in elderly patients; thus, gastrointestinal symptoms should be closely monitored while taking it. Those with a history of peptic ulcers, gastrointestinal bleeding, blood disorders, liver or kidney issues, severe heart failure, hypertension, or allergies to this medication or similar drugs should not take it. Patients with a history of peptic ulcer disease or bleeding, blood abnormalities, liver or kidney issues, decreased heart function, hypertension, asthma, or allergies should use this medication cautiously, and particularly elderly patients should take extra care. If allergic reactions, gastrointestinal bleeding, blood abnormalities, liver or kidney function changes, skin rashes, difficulty breathing, dizziness, or other unusual symptoms occur while taking this medication, it should be stopped immediately and a doctor consulted. This medication should be used at the minimal dose and for the shortest time necessary, and routine blood and liver and kidney function tests should be performed for long-term use. Taking this medication with other non-steroidal anti-inflammatory drugs or certain medications may increase the risk of side effects, so any other medications being taken should be reported. It is advisable not to use this medication during pregnancy, especially in the third trimester, as its use after mid-pregnancy may lead to fetal kidney dysfunction or oligohydramnios. Nursing mothers should avoid this medication as it can pass into breast milk, potentially causing side effects in infants. Children under 2 years of age should avoid this medication, as safety has not been established, and children or elderly should be administered the minimal dose cautiously. In cases of overdose, symptoms such as drowsiness, dyspepsia, and vomiting may occur; thus, appropriate medical treatment should be sought immediately. This medication should be stored out of reach of children, and care should be taken not to transfer it to another container, as this could lead to degradation of its quality.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions (including shock symptoms), hematemesis, gastrointestinal bleeding, peptic ulcer, perforation, severe skin adverse reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis, epidermolysis bullosa, fixed drug eruptions, etc.), jaundice, hepatitis, severe liver abnormalities, kidney disorders, hematuria, renal failure, severe kidney abnormalities, severe headache due to aseptic meningitis,

Mild side effects

• Nausea
• stomach pain
• abdominal pain
• vomiting
• loss of appetite
• dyspepsia
• heartburn
• diarrhea
• constipation
• mouth ulcers

Drug interactions

Do not take this medication with other non-steroidal anti-inflammatory drugs (NSAIDs) and high-dose methotrexate used in chemotherapy. Hydantoin antiepileptic agents, sulfonamides, sulfonylureas, propranolol and other beta-blockers, ACE inhibitors (such as captopril), loop and thiazide diuretics, probenecid, aspirin, lithium, and coumarin anticoagulants (warfarin).

This medication may be sensitive to air or moisture, so it should be stored in a sealed container. Additionally, it is important to maintain a temperature between 1 and 30 degrees Celsius when storing the medication. This will help preserve its effectiveness over time.

Appearance

Blue oval film-coated tablet

Package unit

Domestic - 500 tablets/bottle, Domestic - 100 tablets/box [10 tablets/PTP×10], Export - 100 tablets/box [10 tablets/PTP×10]