Jadimet 12.5/1000 mg (Empagliflozin, Metformin Hydrochloride)

Adult dose

The recommended dose of this medication is 1 tablet, twice a day. The dosage should not exceed the maximum recommended daily dose of empagliflozin 25 mg and metformin 2000 mg. For patients on metformin alone or in combination with insulin or other medications, the recommended dose is empagliflozin 5 mg twice daily (total daily amount 10 mg) along with their existing dose of metformin.

This medication is used for the treatment of diabetes, with two main ingredients acting together to control blood sugar. Care must be taken when taking this medication, as a rare complication known as severe lactic acidosis may occur. Lactic acidosis can lead to hazardous levels of lactic acid in the body and poses a life-threatening risk. Additionally, when taken with other diabetes medications like insulin or sulfonylureas, there is a risk of hypoglycemia, so blood sugar levels should be closely monitored. This medication should not be used in patients with moderate to severe kidney dysfunction, nor in cases of rapidly deteriorating kidney function, severe infections, heart failure, or acute myocardial infarction. If undergoing examinations using iodinated contrast agents, it is imperative to pause taking this medication for a period before and after testing, and it can only be resumed after confirming normal kidney function. It is safest not to use this medication in pregnant or potentially pregnant women or nursing mothers. Regular monitoring of kidney function and blood creatinine levels is recommended while taking this medication to ensure there are no issues. Patients at risk of volume depletion or elderly patients should be cautious of dehydration or hypotension, and the medication can be temporarily discontinued as needed. This medication may increase urine output and raise the risk of urinary tract infections or genital infections, so consult a healthcare professional immediately if symptoms occur. Vitamin B12 levels may decrease over long-term use, so monitoring vitamin B12 levels in the blood is suggested for patients taking this medication for extended periods. When taken with insulin or sulfonylureas, consideration should be given to adjusting the dose of those medications to reduce the risk of hypoglycemia. In cases of overdose, serious side effects such as lactic acidosis may occur, so it is important to take the medication as prescribed by a physician. Safety and efficacy in children have not been established, and it is not recommended for those under 18 years of age. Patients should avoid alcohol consumption while taking this medication, and in special situations such as acute illness or surgery, they should consult with healthcare professionals to potentially pause taking the medication temporarily. Additionally, studies on the effects of this medication on driving or operating machinery are insufficient, so caution is advised. Regular check-ups and consultations with healthcare professionals are important for safe use of this medication, and it is necessary to report any abnormal symptoms immediately.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, lactic acidosis, ketoacidosis, urinary sepsis, pyelonephritis, perineal necrosis, liver function abnormalities, hepatitis, sudden and severe headache, stroke, seizures, altered consciousness, visual disturbances, paralysis, increased creatinine levels in the blood and decreased glomerular filtration rate (acute kidney injury, severe renal impairment), markedly decreased urine output, severe systemic edema, increased blood pressure, myocardial

Mild side effects

• Nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• constipation
• taste disturbances
• itching
• rash
• hives

Store this medication in a tightly sealed container to protect it from air and moisture. It is important to keep the storage temperature between 1 and 30 degrees Celsius to maintain the efficacy of the medication.

Appearance

Biconvex oval film-coated tablets that are dark brownish purple

Package unit

60 tablets/box [10 tablets/PTP x 6], 10 tablets/box [10 tablets/PTP x 1], 60 tablets/bottle, 30 tablets/bottle