Paxlovid Tablet (Nirmatrelvir, Ritonavir)

Adult dose

Nirmatrelvir 300 mg (2 tablets of 150 mg) and Ritonavir 100 mg (1 tablet of 100 mg) should be taken together as a total of 3 tablets orally twice a day (morning and before bedtime) for 5 days. In patients with renal impairment, - Moderate renal impairment (eGFR ≥30 - <60 mL/min): 150 mg of Nirmatrelvir (1 tablet of 150 mg) and 100 mg of Ritonavir (1 tablet of 100 mg) twice a day for 5 days.

This medication contains Ritonavir, a strong CYP3A inhibitor, which may alter the concentration of other medications when taken together. In particular, serious or life-threatening side effects may occur when combined with certain medications, so all current medications must be disclosed to healthcare professionals before taking this drug. This drug should not be administered to patients with hypersensitivity to Nirmatrelvir or Ritonavir, or with certain medical histories. Additionally, its effect may be reduced when taken with CYP3A inducers, therefore co-administration should be avoided. Contains lactose, so caution is needed for patients with lactose intolerance. During the use of this medication, side effects such as taste disturbances and diarrhea may occur, and rarely, serious side effects such as anaphylaxis, skin rash, and liver function abnormalities may occur. Patients with liver disease or liver function abnormalities should exercise caution when using this drug. There is insufficient safety data for use in pregnant women, so it should be used cautiously during pregnancy, and it is recommended to discontinue breastfeeding during treatment and for some time after treatment. Elderly patients may use this drug without special dosage adjustment, but some elderly patients may have higher sensitivity to the medication. In cases of overdose, there is no specific antidote, and the patient should seek medical attention immediately for appropriate treatment. This medication should be kept out of reach of children and stored in its original container to maintain its quality.

Serious side effects

• Anaphylaxis
• hypersensitivity
• toxic epidermal necrolysis
• Stevens-Johnson syndrome
• hepatitis
• jaundice

Mild side effects

• Taste disturbances
• diarrhea
• headache
• hypertension
• abdominal pain
• nausea
• vomiting
• lethargy

This medication may be sensitive to air and moisture, so it should be stored in a sealed container. Furthermore, it is advisable to store the medication at room temperature between 1 degree and 30 degrees Celsius. Storing it this way can ensure the safe efficacy of the medication.

Appearance

This medication is a combination product containing Nirmatrelvir and Ritonavir. - Nirmatrelvir: Pink oval film-coated tablet - Ritonavir: White to nearly white rectangular film-coated tablet

Package unit

30 tablets/box [{(4 tablets of Nirmatrelvir + 2 tablets of Ritonavir)/1 blister} x 5 blisters]