Rozduo Tablet 10/2.5 mg (Ezetimibe, Rosuvastatin Calcium)

Adult dosage

This medication is administered once daily, regardless of meals. For primary hypercholesterolemia, the dosage range is between 10/2.5 mg to 10/20 mg daily. A starting dose of 10/2.5 mg or 10/5 mg per day is recommended. For patients requiring more reduction in LDL-cholesterol, the dosage may be adjusted. After administration, check blood lipid levels at intervals of 4 weeks or more.

This medication may pose a risk of serious muscle problems; therefore, patients who exhibit symptoms of acute severe myopathy or are at risk of renal impairment due to rhabdomyolysis should temporarily suspend or discontinue the medication. This medication should not be administered to certain patients. For example, patients who are allergic to any component of this medication or have active liver disease or muscle disorders, patients with severely impaired renal function, pregnant women or women who may become pregnant, and nursing mothers should not take this medication. Patients at high risk of myopathy or rhabdomyolysis, those with impaired liver function, elderly patients, alcoholics, and those taking certain medications should use this medication carefully under strict medical supervision. Various side effects, including constipation, dyspepsia, muscle pain, headache, dizziness, increased liver enzymes, may occur; therefore, if symptoms arise, patients should consult a doctor immediately. Before taking this medication and during treatment, liver function and muscle enzyme levels should be regularly checked, and if abnormalities are found, the treatment should be suspended or adjusted. This medication should not be administered to pregnant or nursing women; fertile women should practice adequate contraception while taking this medication. Safety and efficacy have not been established in children, so this medication is not recommended for them. Elderly patients are at higher risk for myopathy, so caution should be exercised; however, dosage adjustments are not necessary. This medication may interact with other drugs, so if patients are taking other medications, they must inform their doctor or pharmacist, particularly when combined with cyclosporine, fenofibrate, warfarin, etc. There is no specific antidote for overdose; therefore, appropriate treatment and supportive therapy should be administered based on symptoms, and liver function and muscle enzyme levels should be monitored. This medication should be kept out of reach of children and should not be transferred to other containers.

Serious side effects

Hives, severe swelling (edema), severe allergic reactions, chest tightness, difficulty breathing, cold sweat, pallor, severe rash accompanied by high fever, blisters, skin peeling, pain in oral/ocular mucous membranes, severe skin adverse reactions, shortness of breath or difficulty breathing, asthma attacks, respiratory difficulties with cough + fever, skin or eyes turning yellow (jaundice), extreme lethargy, liver abnormalities (jaundice), sudden and severe

Mild side effects

• Constipation
• dyspepsia
• increased CPK
• colon polyps
• diverticulosis
• COVID-19
• arthralgia
• contusion
• hematoma
• iron deficiency anemia

This medication should be stored in a tightly closed container to protect it from air and moisture. It is recommended to maintain storage temperatures between 1 degree and 30 degrees Celsius. Storing it this way will help safely preserve the medication's efficacy.

Appearance

Yellow rectangular film-coated tablet

Package unit

30 tablets/box [10 tablets/PTP X 3], 30 tablets/bottle, 100 tablets/bottle