DapaHana 10mg (Dapagliflozin Propanediol Hydrate)

Adult dose

The recommended dose of this medication is 10 mg once daily for monotherapy and additional combination therapy with insulin or other blood glucose-lowering agents. For initial combination therapy with metformin, the initial recommended doses are 5 mg once daily or 10 mg once daily. This medication can be taken once daily at any time during the day, irrespective of meals. The tablet must be swallowed whole.

Child dose

The efficacy and safety of dapagliflozin in children under 18 years have not been established. There is no relevant data.

This medication should not be used in patients with hypersensitivity to the active ingredient or excipients, type 1 diabetes, diabetic ketoacidosis, and patients undergoing dialysis. It should be administered with caution to patients with reduced fluid volume or renal dysfunction, as hypotension or rapid changes in kidney function may occur, requiring thorough monitoring of the patient's condition before and during administration. The blood sugar control effect of this medication differs based on renal function, and particularly in patients with moderate to severe impairment of kidney function, the blood sugar control effect may be reduced, necessitating caution. The most commonly reported side effect in clinical trials is genital infections, which may occur more frequently in women and patients with a history of infections. Additionally, hypoglycemia may occur, so when used with insulin or sulfonylureas and other blood glucose-lowering agents, dosage adjustment may be required to reduce the risk of hypoglycemia. Symptoms of dehydration or hypotension due to reduced fluid volume may occur, especially in elderly patients or those on diuretics, requiring additional caution; if symptoms appear, the medication may be temporarily discontinued. The risk of diabetic ketoacidosis is present, so if ketoacidosis symptoms appear regardless of blood glucose levels, immediate testing and treatment should be sought. This medication may increase the risk of urinary tract infections and pyelonephritis, thus rapid evaluation and treatment are necessary if infection symptoms occur. Serious infections such as Fournier's gangrene are rarely reported, and if symptoms such as pain, swelling, or redness in the genitals or perineum appear, medical attention should be sought immediately. Women who are pregnant or planning to become pregnant should not use this medication, and its use is also recommended against for nursing mothers. The safety and efficacy of this medication in children under 18 years of age have not been established and use is not recommended. In case of overdose, there is no specific antidote, so it is important to receive appropriate treatment based on symptoms. This medication does not significantly affect driving or machine operation, but caution is required if there is a risk of hypoglycemia. Lastly, this medication should be stored out of the reach of children, and kept in its original container to maintain quality.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash accompanied by fever, blisters, peeling skin, pain in oral/ocular mucosa, shortness of breath, asthma attack, respiratory abnormality with cough and fever, jaundice (yellowing of skin or eyes), extreme lethargy, sudden and severe headache, lightning pain headache, seizures, confusion, visual disturbances, paralysis, urinary retention

Mild side effects

Vulvovaginitis, balanitis and related genital infections, urinary tract infections, fungal infections, hypoglycemia, dry mouth, dizziness, constipation, back pain, dysuria, polyuria, nocturia, increased hematocrit, elevated serum creatinine, dyslipidemia, weight loss, rash, angioedema, gastrointestinal disorders (gastroesophageal reflux disease, epigastric pain, diverticulitis, intestinal perforation, acute pancreatitis, chronic pancreatitis, chronic gastritis, gastritis, gastrointestinal discomfort, abdominal discomfort, abdomen

This medication is sensitive to air and moisture, so it must be stored in a tightly sealed container. It is best stored at room temperature between 1 to 30 degrees Celsius.

Appearance

Yellow, double convex, diamond-shaped film-coated tablet

Package unit

Bottle - 28 tablets/bottle, Bottle - 30 tablets/bottle, Box - 28 tablets/box [7 tablets/Alu-Alu x 4]