Itraconazole Capsule 100 mg (Itraconazole)

Adult dosage

This medication should preferably be administered immediately after a meal to increase absorption. The capsules must be swallowed whole. 1. Short-term treatment 1) Vulvovaginal candidiasis: Administer itraconazole 200 mg twice daily (morning and evening) for 1 day, or 200 mg once daily for 3 days. 2) Tinea versicolor: Administer 200 mg once daily for 7 days. 3) Tinea corporis and tinea cruris: Administer 100 mg once daily for 15 days. 4) Tinea manuum (interdigital) and tinea pedis (interdigital): Administer 100 mg once daily for 15 days. 5) Tinea manuum (palms) and tinea pedis (soles): Administer 100 mg once daily for 30 days, or 200 mg twice daily for 7 days. 6) Oral candidiasis: Administer 100 mg once daily for 15 days. 7) Fungal keratitis: Administer 200 mg once daily for 21 days. 2. Onychomycosis 1) Pulse therapy Administer 200 mg twice daily for 1 week, followed by a 3-week drug-free period; this constitutes 1 cycle. Administer up to 2 cycles for infection limited to the fingernails, and up to 3 cycles for infection of the toenails. Site of onychomycosis Week 1 Week 2 Week 3 Week 4 Week 5 Week 6 Week 7 Week 8 Week 9 Toenails (with or without concomitant fingernail infection): treatment, drug-free period, treatment, drug-free period, treatment Fingernails: treatment, drug-free period, treatment 2) Continuous therapy Administer 200 mg once daily for 3 months. The therapeutic effect continues for 3 months for fingernails and 6 months for toenails after the end of treatment. 3. Systemic fungal infections In patients with impaired immune function, such as those with neutropenia, AIDS, or organ transplant recipients, the oral bioavailability of this medication may be reduced; if necessary, increase the dose 2-fold. Aspergillosis: 200mg once daily; mean treatment duration 2~5 months. For invasive or disseminated disease, increase the dose to 200mg twice daily. Candidiasis: 100~200mg once daily; mean treatment duration 3 weeks~7 months Cryptococcal meningitis: 200mg twice daily; mean treatment duration 2 months~1 year Maintenance therapy (for AIDS patients only): 200mg once daily2 Paracoccidioidomycosis: 100mg once daily; mean treatment duration 6 months. There are no data on the efficacy of this dosage regimen for the treatment of paracoccidioidomycosis in ADIS patients. 1 The duration of treatment should be adjusted according to the clinical response. 2 The duration of treatment should be based on immune recovery.

This medication should not be used in patients with cardiac dysfunction. It should not be administered to those with heart failure or a history of heart failure. If symptoms of heart failure appear during treatment, use should be discontinued immediately. Patients with allergies to this drug or a history of hypersensitivity to its components should not use it. Additionally, taking this drug with certain medications, particularly those affecting cardiac rhythm, can be extremely dangerous and should be avoided. Pregnant women or those who might become pregnant, as well as nursing mothers, should avoid using this drug. It may harm the fetus during pregnancy, and during breastfeeding, the drug can be transmitted to the baby through breast milk. Caution is required for patients with liver or kidney dysfunction while using this medication. Patients with liver impairment should undergo regular liver function tests, and those with reduced kidney function may need dosage adjustments. Patients with weakened immune systems, such as AIDS patients or organ transplant recipients, may experience reduced efficacy of this drug, so treatment responses should be closely monitored and dosages adjusted as necessary. This drug has many drug interactions; therefore, patients taking other medications should inform their healthcare provider. Caution is especially needed when taking it with heart medications, anticoagulants, anticancer drugs, analgesics, and antipsychotic medications. During treatment with this drug, symptoms such as headache, nausea, abdominal pain may occur, and rarely, liver dysfunction, skin rashes, blood abnormalities, and neurological symptoms may arise. If unusual symptoms occur, consult healthcare personnel immediately. Dizziness or visual disturbances may occur during driving or operating machinery, so caution is necessary. There is no specific antidote for overdose; therefore, it is important to receive treatment according to symptoms. This drug should be kept out of the reach of children and stored in its original container to maintain quality.

Decreased myocardial contractility, headache, nausea, abdominal pain, rhinitis, sinusitis, upper respiratory infection, leukopenia, hypersensitivity, taste disorder, sensory impairment, sensory abnormality, tinnitus, constipation, diarrhea, dyspepsia, abdominal distension, vomiting, liver dysfunction, hyperbilirubinemia, itching, rash, urticaria, polyuria, erectile dysfunction, menstrual disorder, edema, granulocytopenia, thrombocytopenia, anaphylactic reactions, hyperglycemia, hyperkalemia, hypokalemia, hypomagnesemia, confusion, peripheral neuropathy, dizziness, drowsiness, tremors, heart failure, left ventricular failure, tachycardia, hypertension, hypotension, pulmonary edema, speech impairment, cough, gastrointestinal disorders, liver failure, hepatitis, jaundice, erythematous rash, hyperhidrosis, myalgia, arthralgia, renal impairment, urinary incontinence, generalized edema, facial edema, chest pain, fever, pain, fatigue, chills, increased alanine aminotransferase, increased aspartate aminotransferase, increased alkaline phosphatase in the blood, increased lactate dehydrogenase in the blood, increased blood urea, increased gamma-glutamyl transferase, elevated liver enzymes, abnormal urinalysis, leukocytosis, eosinophilia, anemia, vascular edema, serum sickness, angioedema, anaphylaxis, anaphylactic shock, allergic reaction, diplopia, visual impairment, temporary hearing loss, permanent hearing loss, ventricular ectopic beats, atrial block, palpitations, increased intestinal motility, belching, glossitis, stomatitis, abdominal pain in the lumbar region, pancreatitis, increased total serum protein, increased total bilirubin, increased LAP, decreased appetite, malaise, brown urine, increased liver enzyme levels, mucocutaneous syndrome, Stevens-Johnson syndrome, toxic epidermal necrolysis, Riel syndrome, erythema multiforme, hair loss, photosensitivity reaction, exfoliative dermatitis, leukocytoclastic vasculitis, acute generalized exanthematous pustulosis, increased BUN, positive urine protein test, positive urine glucose test, decreased libido, drowsiness, malaise, shoulder stiffness, insomnia, chest pain, elevated serum triglyceride levels, burning sensation, elevated serum uric acid levels, elevated serum potassium levels, serum sickness, angioedema, anaphylactic reactions, hypertriglyceridemia, tremors, visual impairment, congestive heart failure, dyspnea, pancreatitis, significant liver toxicity, toxic epidermal necrolysis, Stevens-Johnson syndrome, acute generalized exanthematous pustulosis, erythema multiforme, exfoliative dermatitis, leukocytoclastic vasculitis, hair loss, photosensitivity, increased serum creatine phosphokinase

This medication should be stored in a tightly closed container to prevent air or moisture from entering. The storage temperature should be maintained between 1 to 30 degrees Celsius.

Appearance

A hard capsule with a blue upper part and a pink lower part, filled with white or grayish spherical pellets.

Package unit

30 capsules/bottle, 100 capsules/bottle