Tenofovir Tablets (Tenofovir Disoproxil Fumarate)

Adult dose

Adults For the treatment of HIV-1 or chronic hepatitis B, take 1 tablet (300mg) once daily. It may be taken with or without food. The optimal duration of treatment for chronic hepatitis B is unknown. Patients with renal impairment For patients with a baseline creatinine clearance <50mL/min, adjust the dosing interval of this medicine by referring to Table 1. No adjustment to the dosing interval is necessary in patients with mild renal impairment (creatinine clearance 50-80mL/min) Table 1 Adjustment of dosing interval according to creatinine clearance ≥50: every 24 hours 30-49: every 48 hours 10-29: every 72-96 hours Patients on hemodialysis: every 7 days or approximately 12 hours after the total dialysis sessionb The pharmacokinetics of tenofovir have not been evaluated in patients with creatinine clearance below 10mL/min who are not receiving hemodialysis; therefore, no dosage recommendations are available for these patients.

Child dose

Pediatric patients 12 years of age and older (35kg or more): For the treatment of HIV-1 or chronic hepatitis B, take 1 tablet (300mg) once daily. It may be taken with or without food. Pediatric patients under 35kg with chronic hepatitis B: Safety and efficacy have not been established. Pediatric patients with renal impairment: There are no data to support dosage recommendations.

This medication is used to treat hepatitis B virus infections. Hepatitis may worsen upon discontinuation, so it is necessary to carefully monitor liver status for several months after discontinuation. Do not take if you have an allergy to this medication or have certain genetic disorders. Caution is needed as it should not be taken in combination with certain other medications. Patients with impaired kidney function or at risk of kidney impairment should undergo regular kidney function tests while taking this medication. Particularly, the risk may increase if taken with medications that are nephrotoxic. It may also affect bone health, so patients at risk of osteoporosis or fractures may consider bone density testing and intake of calcium and vitamin D. This medication contains certain dyes, so patients allergic to these should take it cautiously. It is generally safe to use during pregnancy, but a doctor should be consulted during pregnancy. Nursing mothers should avoid breastfeeding as this medication may pass into breast milk. The safety and efficacy of this medication in children under 12 years of age or weighing less than 35 kg have not been established. Elderly patients over 65 years of age may have reduced kidney and liver function, so they should consult a doctor before use. In case of an overdose, seek medical attention immediately for necessary treatment, and this medication can be removed by blood dialysis. Store this medication at room temperature and keep it out of the reach of children, storing it in its original container for safety.

• Worsening of hepatitis
• hypersensitivity
• acute renal failure
• Fanconi syndrome
• hypophosphatemia
• renal impairment
• bone pain
• limb pain
• fracture
• muscle pain

This medication should be stored in a tightly sealed container to prevent air and moisture exposure, and it is safe to store it at room temperature between 1 to 30 degrees Celsius. Therefore, it is important to avoid direct sunlight and not to store it in excessively hot or cold places to maintain the medication's efficacy.

Appearance

Light blue almond-shaped film-coated tablets

Package unit

30 tablets/bottle