Lightteno Tablet 300 mg (Tenofovir Disoproxil Fumarate)

Adult dose

Adults For the treatment of HIV-1 or chronic hepatitis B, take 1 tablet (300mg) once daily. It may be taken with or without food. The optimal duration of treatment for chronic hepatitis B is unknown. Patients with renal impairment For patients with baseline creatinine clearance <50mL/min, adjust the dosing interval for this medicine as shown in Table 1. For patients with mild renal impairment, no adjustment of the dosing interval is necessary (creatinine clearance 50-80mL/min); regularly monitor calculated creatinine clearance and serum phosphate (see Warning 3). Table 1. Adjustment of dosing interval according to creatinine clearance Creatinine clearance (mL/min)a ≥50: every 24 hours Creatinine clearance (mL/min)a 30-49: every 48 hours Creatinine clearance (mL/min)a 10-29: every 72-96 hours Patients receiving hemodialysis: every 7 days or approximately 12 hours after dialysisb The pharmacokinetics of tenofovir have not been evaluated in patients with creatinine clearance below 10mL/min who are not receiving hemodialysis; therefore, no dosing recommendations are available for these patients. a. Calculated using ideal (lean) body weight. b. The dose is administered once weekly, generally assuming three hemodialysis sessions of approximately 4 hours each per week. This medicine should be administered after dialysis is completed.

Child dose

Pediatric patients aged 12 years and older (35kg or more): For the treatment of HIV-1 or chronic hepatitis B, take 1 tablet (300mg) once daily. It may be taken with or without food. Pediatric patients weighing less than 35kg with chronic hepatitis B: Safety and efficacy have not been established. Pediatric patients with renal impairment: There are no data to support a dosing recommendation.

This drug can cause serious liver problems, so patients with compromised liver function or at risk of liver disease should take special precautions. Abruptly discontinuing treatment can worsen hepatitis, so patients should be closely monitored for a long period of time even after stopping the medication. Since this drug is primarily excreted through the kidneys, patients with impaired kidney function should check their kidney status before taking the medication and undergo regular kidney function tests during treatment. When taken with other medications, interactions can occur; therefore, it is advisable not to take this drug with medications that affect the kidneys. This drug should be used cautiously according to a professional treatment plan for patients with both HIV and hepatitis B, and an HIV test must be performed before starting treatment. Bone density may decrease, raising the risk of fractures; therefore, patients at risk of osteoporosis should regularly check their bone health and consider calcium and vitamin D supplementation if necessary. Changes in body fat distribution may occur, so patients should closely monitor weight and body shape changes. During the immune system recovery process, inflammatory responses or autoimmune diseases may occur, so early symptoms should be carefully monitored during initial treatment. This drug contains lactose; therefore, patients with certain genetic conditions such as lactose intolerance should not take it. It should only be used during pregnancy if necessary, and breastfeeding mothers are advised to avoid nursing as the medication can be transferred to the baby. It is generally recommended not to use this medication in children under 12, as its safety and efficacy have not been established. Elderly patients should take caution as drug responses may vary due to decreased kidney function. In case of overdose, consult medical personnel immediately, and if necessary, medications can be removed through hemodialysis. Store the medication out of reach of children and keep it in its original container for safety.

Severe liver enlargement accompanied by jaundice and fatty liver, exacerbation of hepatitis, acute renal failure, Fanconi syndrome, rash, diarrhea, headache, pain, depression, weakness, nausea, dizziness, indigestion, vomiting, fatty metamorphosis, arthralgia, myalgia, insomnia, peripheral neuropathy, anxiety, pneumonia, fever, abdominal pain, lower back pain, appetite loss, abdominal distension, fatigue, sinusitis, upper respiratory infection, nasopharyngitis, nausea, vomiting, fatigue, sweating, weight loss, pneumonia, allergic reaction, hypokalemia, hypophosphatemia, dyspnea, pancreatitis, increased amylase, hepatic steatosis, hepatitis, increased liver enzymes, rhabdomyolysis, osteomalacia, muscle weakness, myopathy, acute renal failure, acute tubular necrosis, interstitial nephritis, nephrogenic diabetes insipidus, increased creatinine, proteinuria, polyuria, weakness, indigestion, constipation, gastroesophageal reflux disease, ascites, abdominal distension, urinary tract infection, gastroenteritis, shingles, septic shock, worsening condition, increased ALT, increased AST, hepatocellular carcinoma, metastatic brain tumor, osteoporosis, flank pain, spinal pain, sensory loss, cerebral infarction, diabetic neuropathy, metabolic encephalopathy, seizures, cholelithiasis, cirrhosis, alcoholic sclerosing, liver failure, liver fibrosis, hand fractures, fever-induced neutropenia, leukopenia, deep vein thrombosis, corneal degeneration, graft-versus-host disease, hair loss, erythema multiforme, sialadenitis, ingrown toenails, urticaria, muscular fiber inflammation, herniated disc, osteoarthritis, limb pain, dementia, confusion, sleep disorders, bladder dysfunction, urolithiasis, dysuria, renal cysts, ureterolithiasis, anemia, splenomegaly, thrombocytopenia, decreased appetite, eating disorders, cough, rhinitis, upper respiratory cough syndrome, hypertension, conjunctival hemorrhage, ocular movement disorders, ocular congestion, benign prostatic hyperplasia

This medication may be sensitive to air and moisture, so it should be stored in a tightly sealed container. The recommended storage temperature is room temperature between 1°C and 30°C. Storing it this way helps maintain the drug's efficacy for a longer period.

Appearance

Light blue almond-shaped film-coated tablet

Package unit

30 tablets/bottle