Dirukan 150 Milligrams (Fluconazole)

Adult dose

The route of administration should be determined according to the patient's clinical condition. Absorption of the oral formulation is rapid and nearly complete; therefore, the doses of oral formulations (tablets, capsules, dry syrup) and injectable formulations are the same. ○ Adults 1. Vaginal candidiasis: Administer fluconazole 150 mg orally as a single dose. 2. Systemic candidiasis, including candidemia, disseminated candidiasis, and other invasive Candida infections (peritoneal, endocardial, pulmonary, urinary tract, etc.): The usual dose is 400 mg once on the first day, followed by 200 mg once daily from the next day. The dose may be increased to 400 mg once daily according to the patient's response. The duration of treatment should be determined according to clinical response and medical judgment. 3. Cryptococcal meningitis and cryptococcosis at other sites: The usual dose is 400 mg once on the first day, followed by 200-400 mg once daily from the next day. The duration of treatment is determined by clinical and mycological response, but treatment should usually continue for at least 6 ~ 8 weeks. 4. To prevent recurrence of cryptococcal meningitis in patients with AIDS, after completion of initial treatment, administer 200 mg once daily indefinitely. 5. Prevention of fungal infections in immunocompromised patients at risk of fungal infections due to neutropenia resulting from cytotoxic chemotherapy, radiation therapy, or bone marrow transplantation: Administer 50-400 mg once daily according to the patient's risk of fungal infection. A dose of 400 mg once daily is recommended for patients at very high risk of systemic fungal infections, such as bone marrow transplant patients with severe neutropenia or an anticipated prolonged period of neutropenia. In these patients, administer 400 mg starting 5-6 days before the anticipated onset of neutropenia and continue 400 mg for 1 week after the neutrophil count has increased to 1,000 cells/mm3 or more. 6. For onychomycosis, administer 150 mg once weekly until the fingernails or toenails have regrown (until new, uninfected nails have grown). Regrowth of a new fingernail usually takes 3-6 months, and a toenail takes 6-12 months; growth rates may vary between individuals and with age. After successful treatment with long-term administration, nails may sometimes remain damaged. Dermatophyte skin infections, including athlete's foot (tinea pedis), tinea corporis, jock itch (tinea cruris), and cutaneous candidiasis: The usual dose is 50 mg once daily or 150 mg once weekly for 2-4 weeks. However, athlete's foot may require treatment for 6 weeks, depending on the course of the infection. For tinea versicolor, administer 50 mg once daily for 2-4 weeks. ○ Elderly patients If renal function is normal, the usual adult dose may be administered. In patients with renal impairment (creatinine clearance 50 mL/min or less), reduce the dose or increase the dosing interval. ○ Patients with renal impairment This medicine is excreted mainly in the urine unchanged. No dose adjustment is necessary for a single dose. If multiple doses are required, administer the usual dose only on the first day and adjust the dose from the following day as follows. Creatinine clearance (mL/min) > 50: 100% of the usual dose Creatinine clearance (mL/min) ≤50 (not receiving dialysis): 50% of the usual dose Patients receiving hemodialysis: 100% of the usual dose after each hemodialysis session Patients receiving hemodialysis should receive 100% of the usual dose after each hemodialysis session. On days when dialysis is not performed, administer a reduced dose according to creatinine clearance.

This medication should not be used in certain patients. Women who are allergic to this drug or similar drugs, or who are pregnant or breastfeeding, should not take it. Additionally, it should not be combined with certain medications as serious side effects may occur. This medication should be used cautiously in patients with renal or liver function problems, as well as those with heart disease or a risk of arrhythmias. Liver function should be closely monitored, especially as it may deteriorate. This drug can interact with various other medications, so it is essential to consult a doctor or pharmacist if taking other medications. Generally, this drug is well tolerated, but rare side effects may occur such as blood abnormalities, allergic reactions, liver dysfunction, skin rashes, gastrointestinal disturbances, arrhythmias, etc. If side effects are suspected, immediate medical attention should be sought. Regular blood tests, liver and kidney function tests should be performed during treatment, and especially if liver enzyme levels increase, the treatment should be re-evaluated. Patients with heart disease or electrolyte imbalances should have their heart condition monitored carefully using an electrocardiogram. Women who are pregnant or may become pregnant must consult a doctor before taking this medication, and effective contraception should be used during treatment. Breastfeeding women are also advised against taking this medication. The safety in children, particularly infants under 6 months, has not been sufficiently established, so it should only be used with caution when necessary. Care should be taken when driving or operating machinery as dizziness or seizures may occur due to this medication. In case of overdose, hallucinations or abnormal behavior may occur; immediate medical attention is required, and blood dialysis can help lower the medication concentration in the body.

Agranulocytosis, leukopenia, neutropenia, thrombocytopenia, anaphylaxis, angioedema, hypertriglyceridemia, hypercholesterolemia, hypokalemia, insomnia, drowsiness, headache, seizures, dizziness, paresthesia, dysgeusia, tremor, vertigo, Torsade de pointes, QT prolongation, abdominal pain, diarrhea, nausea, vomiting, dyspepsia, bloating, dry mouth, increased ALT, increased AST, increased serum alkaline phosphatase, cholestasis, jaundice, increased bilirubin, hepatotoxicity, liver failure, hepatocellular necrosis, hepatitis, hepatocellular injury, rash, itching, urticaria, increased sweating, drug rash, toxic epidermal necrolysis, Stevens-Johnson syndrome, acute generalized exanthematous pustulosis, exfoliative dermatitis, facial edema, hair loss, drug reaction with eosinophilia and systemic symptoms (DRESS), myalgia, fatigue, malaise, weakness, fever, hallucinations, behavioral disturbance

This medication may be sensitive to air or moisture, so it should be stored in a tightly sealed container. It's important to maintain a temperature between 1°C and 30°C, avoiding extremes of heat or cold, to preserve the medication's efficacy.

Appearance

Pink rectangular tablet

Package unit

30 tablets/bottle