Tenofovir Tablets (Tenofovir Disoproxil Fumarate)

Adult dose

Adults: For the treatment of HIV-1 or chronic hepatitis B, take 1 tablet (300mg) once daily. It may be taken with or without food. The optimal duration of treatment for chronic hepatitis B is unknown. No adjustment to the dosing interval is necessary for patients with mild renal impairment (creatinine clearance 50-80mL/min). Creatinine clearance ≥50mL/min: Recommended dosing interval for 300mg is every 24 hours Creatinine clearance 30-49mL/min: Recommended dosing interval for 300mg is every 48 hours Creatinine clearance 10-29mL/min: Recommended dosing interval for 300mg is every 72-96 hours Patients on hemodialysis: Recommended dosing interval for 300mg is every 7 days or approximately 12 hours after the total dialysis session

Child dose

Pediatric patients aged 12 years or older (35kg or more): For the treatment of HIV-1 or chronic hepatitis B, take 1 tablet (300mg) once daily. It may be taken with or without food. Pediatric patients with chronic hepatitis B weighing less than 35kg: Safety and efficacy have not been established.

This medication may exacerbate hepatitis upon discontinuation of treatment, so the condition should be closely monitored for several months after stopping. You should not take this medication if you are allergic to any of its components or have certain genetic problems such as lactose intolerance. This medication should not be taken with specific other drugs, so you must inform your doctor or pharmacist before taking it. Patients with kidney function problems or who are at risk of kidney impairment should undergo regular kidney function tests before and during the treatment and adjust the treatment as necessary. This medication may affect bone health, so patients at risk for osteoporosis or fractures should check their bone health status and consider supplementation with calcium and vitamin D if necessary. While taking this medication, side effects such as gastrointestinal disturbances, headaches, fatigue, and depression may occur, so consult your healthcare provider if you notice any unusual symptoms. Pregnant women may use this medication if necessary, but they should consult their healthcare provider before use, and breastfeeding is not recommended during treatment. The safety and efficacy of this medication have not been established for children under 12 years of age or those weighing less than 35 kg, so it should not be used in these populations. Elderly patients should take caution and consider liver, kidney, heart function decline, and any underlying diseases or medications. In case of overdose, immediately contact a healthcare facility to receive appropriate treatment, and some of this medication can be removed via hemodialysis. Store this medication at room temperature, keep it out of reach of children, and it is safe to store in its original container.

• Worsening of hepatitis
• acute kidney failure
• Fanconi syndrome
• hypophosphatemia
• bone pain
• limb pain
• fractures
• muscle pain
• proximal tubular dysfunction
• rash

This medication may be sensitive to air or moisture, so it should be stored in a sealed container. Additionally, it is best to store the medication at room temperature between 1 to 30 degrees Celsius. This helps maintain the medication's effectiveness and ensures safe use.

Appearance

Pale blue almond-shaped film-coated tablet

Package unit

Bottle - 30 tablets/bottle