Bipito Tablet 20mg (Atorvastatin Calcium Trihydrate)

Adult dosage

For hyperlipidemia: The recommended initial dose is 10 mg of atorvastatin once daily. For patients requiring a larger reduction in LDL-cholesterol levels, treatment may start at 20 mg or 40 mg once daily. This medication is administered within a dosage range of 10 mg to 80 mg once daily. Dosage should be individualized according to treatment goals and responses, with lipid levels analyzed and adjusted within 2 to 4 weeks. The goal of treatment is to lower LDL-cholesterol levels, and it is recommended to use LDL-cholesterol levels for assessing the start of treatment and treatment response. However, if LDL-cholesterol levels cannot be utilized, total cholesterol levels may be used to monitor treatment response. In patients with homozygous familial hypercholesterolemia, the dosage is 10 mg to 80 mg once daily, used either in conjunction with other lipid-lowering therapies (e.g., LDL apheresis) or when such therapies are not feasible. For pediatric patients with heterozygous familial hypercholesterolemia (ages 10 to 17): The recommended initial dosage of this medication is 10 mg per day, with a recommended maximum dosage of 20 mg per day (there are no clinical data administering over 20 mg for this age group). Dosage should be appropriately adjusted based on the recommended treatment goals for individual patients and should be adjusted at intervals of 4 weeks or more. ○ In patients with kidney disease: Kidney disease does not affect the plasma concentration of atorvastatin or its LDL-cholesterol lowering effects, so dosage adjustment is unnecessary. ○ In elderly patients: The efficacy and safety in patients over 70 years of age are similar to those observed in the general adult patient population.

Children's dosage

For pediatric patients with heterozygous familial hypercholesterolemia (ages 10 to 17): The recommended initial dosage is 10 mg once daily, with a maximum dosage of 20 mg once daily. The dosage should be adjusted at intervals of at least 4 weeks.

This medication may cause muscular symptoms; if there is severe muscle pain or weakness or if creatine kinase levels are significantly elevated, discontinue immediately and consult with a doctor. This medication should not be used in patients with certain liver diseases or muscle disorders, in pregnant or potentially pregnant women, in breastfeeding women, in children under 10 years of age, or in patients taking certain other medications. Patients with a history of alcohol abuse or liver disease, patients with impaired kidney function, hypothyroidism patients, and the elderly need to be especially cautious while using this medication and must undergo regular check-ups as directed by their physician. This medication can cause various side effects such as liver dysfunction, gastrointestinal symptoms, headaches, muscle pain, and allergic reactions; if any abnormal symptoms occur, inform a healthcare professional immediately. This medication is metabolized in the liver, hence, dosage adjustments may be necessary for patients with liver dysfunction, and treatment should be discontinued if symptoms of hepatitis (nausea, vomiting, lethargy, etc.) occur. While taking this medication, if symptoms like muscle pain, weakness, or fever appear, consult a physician immediately and get tested. This medication may interact with other drugs; therefore, caution is necessary, particularly when taken with certain antibiotics, antifungals, antivirals, immunosuppressants, grapefruit juice, etc. Women of childbearing age should use appropriate contraception while taking this medication, and must discontinue if pregnancy occurs. This medication is not recommended for breastfeeding women; breastfeeding should be stopped. Elderly patients or those with kidney disorders may have a higher risk of muscle-related side effects while taking this medication; careful monitoring is required. In case of overdose, there is no specific antidote available, and treatment should be symptomatic; regular checks of liver function and muscle-related tests are necessary. This medication should be stored out of reach of children and kept in its original container.

Serious side effects

Hives, severe swelling (angioedema, allergic edema), chest tightness, difficulty breathing, cold sweats, pallor, acute and severe myopathy, rhabdomyolysis, kidney failure, severe skin reactions (with fever, severe rashes, blisters, peeling skin, pain in oral/eye mucous membranes, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis), breathing problems (dyspnea, asthma attacks, cough accompanied by fever)

Mild side effects

• Weakness
• fatigue
• chest pain
• peripheral edema
• tiredness
• fever
• rhinitis
• hyperglycemia
• hypoglycemia
• weight gain

This medication should be stored in a tightly closed container to prevent air or moisture from entering, and it is safe to store at temperatures between 1 degree and 30 degrees Celsius.

Appearance

White oval film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle