Nutraconazole 100 mg (Itaconazole)

Adult dosage

It is preferable to administer this medicine immediately after a meal. 1. Short-term treatment 1) Candidal vaginitis: Administer itraconazole 200 mg twice daily (morning and evening) for 1 day, or 200 mg once daily for 3 days. 2) Pityriasis versicolor: Administer 200 mg once daily for 7 days. 3) Tinea corporis, tinea cruris (jock itch): Administer 100 mg once daily for 15 days. 4) Tinea manuum (interdigital type), tinea pedis (interdigital type): Administer 100 mg once daily for 15 days. 5) Tinea manuum (palms), tinea pedis (soles): Administer 100 mg once daily for 30 days, or 200 mg twice daily for 7 days. 6) Oral candidiasis: Administer 100 mg once daily for 15 days. 7) Fungal keratitis: Administer 200 mg once daily for 21 days. 2. Onychomycosis 1) Pulse therapy Administer 200 mg twice daily for 1 week, followed by a 3-week treatment-free period; this constitutes 1 cycle. Administer up to 2 cycles if only the fingernails are infected and up to 3 cycles if the toenails are infected. 2) Continuous therapy Administer 200 mg once daily for 3 months. 3. Systemic fungal infections In patients with impaired immune function, such as those with neutropenia, AIDS, or organ transplant recipients, the oral bioavailability of this medicine may be reduced. If necessary, double the dose. Aspergillosis: 200mg once daily; average treatment duration 2～5 months. For invasive or disseminated disease, increase to 200mg twice daily. Candidiasis: 100～200mg once daily; average treatment duration 3 weeks～7 months. Cryptococcal meningitis: 200mg twice daily; average treatment duration 2 months～1 year. Maintenance therapy: 200mg once daily. Paracoccidioidomycosis: 100mg once daily; average treatment duration 6 months

It is important not to administer this drug to patients with compromised heart function, especially those with congestive heart failure. If symptoms of heart failure appear, discontinue use immediately. Those who have allergic reactions or hypersensitivity to this medication should not use it. Additionally, it may be dangerous to take this drug with certain heart-related medications or various other drugs, so consultation with a doctor or pharmacist is essential. Women who are pregnant or may become pregnant, as well as those who are breastfeeding, should not take this medication and should implement effective contraception after use. Patients with impaired liver or kidney function may face an increased risk of side effects from this drug, requiring careful monitoring and possibly dosage adjustments. Since this drug is primarily metabolized in the liver, regular liver function tests should be conducted, and treatment should be discontinued immediately if signs of liver damage occur. Side effects such as headaches, nausea, abdominal pain, and skin rashes or itching may occur, so caution is warranted. Dizziness or visual and auditory disturbances can occur, necessitating caution while driving or operating machinery. This drug interacts with many other medications, with some being contraindicated for concurrent use; therefore, inform healthcare providers of any other medications being taken. There is no specific antidote for overdose, so immediate medical attention is required, and it is not removed by hemodialysis. Keep out of reach of children and store in the original container to prevent misuse or quality deterioration.

Headache, nausea, abdominal pain, rhinitis, sinusitis, upper respiratory infection, leukopenia, hypersensitivity, taste disorder, sensory impairment, sensory abnormality, tinnitus, constipation, diarrhea, dyspepsia, bloating, vomiting, liver dysfunction, hyperbilirubinemia, itching, rash, urticaria, polyuria, erectile dysfunction, menstrual disorders, edema, granulocytopenia, thrombocytopenia, anaphylactoid reaction, hyperglycemia, hyperkalemia, hypokalemia, hypomagnesemia, confusion state, peripheral neuropathy, dizziness, drowsiness, tremor, heart failure, left ventricular failure, tachycardia, hypertension, hypotension, pulmonary edema, speech disturbance, cough, gastrointestinal disorders, liver failure, hepatitis, jaundice, erythematous rash, hyperhidrosis, myalgia, arthralgia, kidney disorder, urinary incontinence, generalized edema, facial edema, chest pain, fever, pain, fatigue, chills, increased alanine aminotransferase, increased aspartate aminotransferase, increased serum alkaline phosphatase, increased serum lactate dehydrogenase, increased blood urea, increased gamma-glutamyl transferase, increased liver enzymes, abnormal urinalysis, leukocytosis, eosinophilia, anemia, vascular edema, serum sickness, angioedema, anaphylaxis, anaphylactic shock, allergic reaction, diplopia, visual impairment, hearing loss, ventricular extrasystole, atrioventricular block, palpitations, increased bowel motility, belching, glossitis, stomatitis, abdominal pain in the lower back, pancreatitis, increased serum total protein, increased total bilirubin, increased LAP, decreased appetite, malaise, brown urine, sicca syndrome, Stevens-Johnson syndrome, toxic epidermal necrolysis, Riel syndrome, erythema multiforme, hair loss, photosensitivity reaction, exfoliative dermatitis, leukocytoclastic vasculitis, acute generalized exanthematous pustulosis, increased BUN, positive proteinuria, positive glucosuria, decreased libido, drowsiness, shoulder stiffness, insomnia, chest pain, increased serum triglyceride level, burning sensation, increased serum uric acid level, increased serum potassium level, serum sickness, angioedema, anaphylactic reaction, hypertriglyceridemia, tremor, visual impairment, transient or permanent hearing loss, congestive heart failure, dyspnea, pancreatitis, significant hepatotoxicity, toxic epidermal necrolysis, Steven-Johnson syndrome, acute generalized exanthematous pustulosis, erythema multiforme, exfoliative dermatitis, leukocytoclastic vasculitis, hair loss, photosensitivity, increased serum creatine phosphokinase activity

Store this medication in a sealed container to prevent air or moisture ingress, and it is advisable to keep it at room temperature between 1 to 30 degrees Celsius. Proper storage helps maintain the drug's efficacy.

Appearance

White or yellowish round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle