Clarithromycin 250 mg tablet

Adult dosage

Adults: The usual dose of clarithromycin is 250 mg (potency) twice daily. For severe infections, administer 500 mg (potency) twice daily. The usual treatment duration is 7 ～ 14 days. In patients with renal impairment and a creatinine clearance of 30 mL/min or less, the dose should be reduced by half: 250 mg (potency) once daily, or, for severe infections, 250 mg (potency) twice daily. Do not administer for more than 14 days to these patients. Mycobacterial infections: Administer 500 mg (potency) twice daily. In this case, it must be administered concomitantly with other antimycobacterial agents, such as ethambutol, clofazimine, and rifampin. Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500 mg (potency) three times daily with omeprazole 40 mg once daily for 14 days, followed by omeprazole 40 mg once daily for 14 consecutive days. In other words, administer clarithromycin 500 mg (potency) three times daily for 14 days (days 1–14) and omeprazole 40 mg once daily for 28 days (days 1 ～ 28).

Children's dosage

Children aged 12 years and older: Same as for adults. For children under 12 years of age, use clarithromycin dry syrup.

This medication should not be used in certain patients. For example, it should not be administered to patients with allergies to any of its ingredients, or those with hypersensitivity to antibiotics in a related class. Additionally, patients with certain heart diseases or severely impaired liver or kidney function should not use this medication. Pregnant or breastfeeding women should also refrain from taking it. Patients with weakened liver or kidney function, those with heart disease, and elderly patients should use this medication with caution. If taking other antibiotics or certain medications, there may be interactions, so caution is advised. During treatment, allergic reactions, gastrointestinal disturbances, liver dysfunction, kidney dysfunction, skin rashes, and central nervous system symptoms may occur, so patients should immediately consult a healthcare professional if any unusual symptoms arise. This medication has a high potential for drug interactions, especially when taken with medications that affect the heart or are metabolized in the liver, so it is important to inform healthcare professionals. Furthermore, when used with hypoglycemic agents or certain immunosuppressants and anticoagulants, attention should be paid to changes in blood concentration and side effects. Pregnant or breastfeeding women should avoid this medication unless absolutely necessary and should consult with a healthcare provider. Children and elderly patients may require dosage adjustments or special precautions. In case of overdose, gastrointestinal disturbances or severe central nervous system symptoms may arise, and emergency treatment should be sought immediately. It is crucial to adhere to the prescribed duration and dosage to prevent antibiotic resistance during the use of this medication.

Shock, anaphylactic symptoms, dyspnea, seizures, erythema, rash, itching, urticaria, mild skin erythema, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, discomfort, flatulence, diarrhea, oral mucosal ulceration, upper abdominal pain, dry mouth, transient tooth discoloration, pancreatitis, elevated amylase, taste disturbances, anorexia, constipation, discoloration of stool, pseudomembranous colitis, hemorrhagic colitis, fever, cough, dyspnea, chest X-ray abnormalities, eosinophilia, eosinophilic lung infiltration, interstitial pneumonia, chronic bronchitis, acute exacerbation of acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, seizures, tremors, numbness, behavioral changes, manic behavior, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash accompanied by eosinophilia and systemic symptoms, jaundice, hepatocellular hepatitis, cholestatic hepatitis, elevated liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, elevated γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, elevated serum creatinine, elevated BUN, interstitial nephritis, renal failure, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, malaise, headache, taste distortion, hearing loss, paresthesia, arthralgia, myalgia, olfactory disturbances, tinnitus, auditory impairment, hypoglycemia, purpuric rash, acute generalized exanthematous pustulosis, cellulitis, candidiasis, gastroenteritis, infections, vaginal infections, leukopenia, neutropenia, thrombocytosis, agranulocytosis, thrombocytopenia, anaphylactoid reaction, vascular edema, decreased appetite, insomnia, neurosensitivity, noise perception, psychotic disorder, confusional state, non-vertiginous dizziness, drowsiness, tremor, dyskinesia, vertiginous dizziness, hearing loss, cardiac arrest, atrial fibrillation, ectopic beats, palpitations, vasodilation, asthma, epistaxis, pulmonary embolism, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, bloating, tongue discoloration, tooth discoloration, abnormal liver function tests, cholestasis, hepatitis, elevated alanine aminotransferase, elevated aspartate aminotransferase, elevated gamma-glutamyl transferase, hepatocellular jaundice, vesicular dermatitis, hyperhidrosis, papular rash, acne, Henoch-Schonlein purpura, muscle cramps, musculoskeletal rigidity, myopathy, nephritis, phlebitis at the injection site, pain at the injection site, inflammation at the injection site, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, abnormal urine color, changes in mental intake, compulsive behavior, hypokalemia, hypoxemia

This medication may be sensitive to light, so it should be stored away from direct sunlight in a dark place. The storage temperature should be maintained at room temperature between 1 to 30 degrees Celsius, and it is important to store the medication in a tightly sealed container to avoid contact with air.

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle