Espam Injection (Nepafenac Hydrochloride)

Adult administration

Administer 20 mg of nefopam hydrochloride by intramuscular or intravenous injection per dose. If necessary, repeat every 6 hours, not exceeding 120 mg per day. Administer intravenous injections slowly over at least 15 minutes. After administration, it is preferable to have the patient lie still and rest for 15-20 minutes. If administered in an infusion solution such as an electrolyte or glucose solution, administer 30 mg over 4 hours or 40 mg over 6-8 hours, according to the infusion duration. It is recommended to avoid mixing this drug with other drugs for injection. The dose may be adjusted as appropriate according to age and symptoms.

Since this medication is an injectable ampoule, caution is required when cutting the glass container to minimize the inclusion of glass fragments. It should not be administered to patients with epilepsy, patients who have had a myocardial infarction, patients taking MAO inhibitors, patients with hypersensitivity to this medication or its components, children under 15 years of age, patients with a history of seizures, patients at risk of urinary retention due to urethral and prostate disorders, and patients with angle-closure glaucoma. Elderly individuals, pregnant and nursing women, and patients taking anticholinergic agents should exercise special caution when using this medication. This medication may cause various side effects such as loss of appetite, nausea, drowsiness, vomiting, excessive sweating, dizziness, palpitations, dry mouth, urinary retention, injection site pain, headache, blurred vision, fatigue, nervous irritability, sleep disturbances, hallucinations, drug dependence, seizures, and allergic reactions. If any unusual symptoms occur, consult with a healthcare professional immediately. This medication is not a treatment for the underlying causes of inflammation or pain but is used to relieve symptoms, thus it should be used while considering the degree of acute inflammation or pain and it is advisable to avoid long-term use. When used for infectious inflammation, it should be administered with appropriate antibiotics or antifungals and observed closely. Elderly individuals should be particularly cautious of side effects using the minimum effective dose. Patients with liver or kidney dysfunction may be affected by the metabolism and excretion of this medication, requiring caution. This medication may cause drowsiness or decreased concentration, therefore it is advisable to avoid using it when driving or operating machinery or engaging in hazardous activities. When used in conjunction with other anti-inflammatory or specific central nervous system medications, side effects may increase, so consult a healthcare professional before concomitant use. Use of this medication during pregnancy or breastfeeding is not recommended. Safety and efficacy in children under 15 years of age have not been established; they should not use this medication. In cases of overdose, serious symptoms such as cardiovascular abnormalities, seizures, and hallucinations may occur, so consult a doctor or pharmacist immediately and receive appropriate treatment. Mixing this medication with other medications for injection is not recommended, and it should be stored in a cool, dry place out of reach of children, avoiding direct sunlight. Additionally, to prevent misuse, it should not be transferred to another container.

• Loss of appetite
• gastrointestinal disturbance
• nausea
• drowsiness
• vomiting
• hyperhidrosis
• dizziness
• tachycardia
• palpitations
• thirst

This medication should be stored in a sealed container to prevent air or moisture from entering, ideally at room temperature between 1 to 30 degrees Celsius. This helps maintain the effectiveness of the medication.

Appearance

A colorless, transparent injection solution in a colorless, transparent glass ampoule.

Package unit

2mL/ampoule x 10 pieces, 4mL/ampoule x 10 pieces