Anikra Tablet 375 mg (Amoxicillin Trihydrate - Clavulanate Potassium (2:1))

Adult dose

Adults and children over 12 years or weighing 40 kg or more: Administer orally 250 mg/125 mg of amoxicillin/clavulanate potassium three times daily (every 8 hours). In case of severe or respiratory infections, the dose may be increased to 500 mg/125 mg per dose. In patients with renal impairment, adjust the dose based on creatinine clearance. - Creatinine clearance of 30 mL/min or higher: No dose adjustment required.

Child dose

Children under 12 years or weighing less than 40 kg: Administer with dosage reduced, similar to adults.

This drug is a beta-lactam antibiotic and should not be administered to patients who are hypersensitive to penicillin or have previously experienced severe allergic reactions. Particularly, caution is needed for patients with infectious mononucleosis or lymphocytic leukemia as there may be an increased risk of rash. Patients with a history of liver function issues should use this medication cautiously as liver dysfunction may recur. Patients with liver impairment should consult healthcare providers before taking this medication. Patients with moderate to severe kidney impairment may experience elevated drug concentration, and administration intervals should be adjusted. Those with allergic predispositions or family histories, especially those with asthma or hives, should take caution. Patients who have difficulty with oral intake, elderly patients, or those in poor general condition may exhibit symptoms of vitamin K deficiency and should be monitored. Patients with gastrointestinal diseases causing nausea or diarrhea may not adequately absorb the medication. This drug may cause gastrointestinal side effects such as diarrhea, dyspepsia, and vomiting; in severe cases, pseudomembranous colitis may develop, so treatment should be discontinued immediately if symptoms worsen. Symptoms of liver dysfunction have also been reported, necessitating careful observation during and after treatment, particularly in elderly men. Rarely, skin rashes, itching, and severe skin reactions may occur, and if these symptoms arise, the medication should be stopped and the physician's orders followed. Hematological adverse reactions such as leukopenia, anemia, and thrombocytopenia have been reported, so medical consultation is necessary if abnormal symptoms occur. Central nervous system side effects like headaches, dizziness, and seizures may occur rarely, especially in patients with reduced kidney function. Kidney function abnormalities may occur, thus regular testing is recommended. This medication may interact with other drugs, so patients must inform healthcare providers of any current medications. Pregnant women or those who may become pregnant should consult healthcare providers before using this medication, especially during the first three months of pregnancy. In breastfeeding mothers, this drug may be passed into breast milk and could cause side effects in infants, so caution is advised. This medication is not recommended for children under 12 years or those weighing less than 40 kg. Elderly patients may have an increased risk of side effects due to decreased physiological functions; therefore, dosage and administration intervals should be adjusted carefully. In cases of overdose, symptoms such as abdominal pain, diarrhea, vomiting, rash, and seizures may appear, and the medication should be discontinued immediately with appropriate treatment.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, pain in mucous membranes of mouth/eyes, shortness of breath or difficulty breathing, asthma attacks, respiratory distress with cough and fever, yellowing of skin or eyes (jaundice), extreme lethargy, sudden and intense headaches, lightning headache, seizures, confusion, visual disturbances, paralysis, urination

Mild side effects

Diarrhea, dyspepsia, stomatitis, gastritis, glossitis, nausea, vomiting, loss of appetite, abdominal pain, bloating, constipation, colonic pain, acidity, soft stools, dry mouth, acute pancreatitis, candidiasis, antibiotic-associated colitis, bloody stools, nausea with high-dose intake, elevation of AST/ALT/ALP/LDH/serum bilirubin, hepatitis, cholestatic jaundice, itching, erythema multiforme, angioedema, serum sickness syndrome, hypersensitivity vasculitis, acute

This medication should be stored in a sealed container to prevent moisture and kept in a cool temperature between 1 to 25 degrees Celsius. Proper storage maintains the drug's efficacy over time.

Appearance

It is a white or almost white oval film-coated tablet.

Package unit

80 tablets/PTP, 100 tablets/PTP