Fluconazole 150 mg Tablets (Fluconazole)

Adult dose

The route of administration should be determined according to the patient's clinical condition. Since oral formulations are absorbed rapidly and almost completely, the doses of oral formulations (tablets, capsules, dry syrup) and injectable formulations are the same. ○ Adults 1. Vaginal candidiasis: Administer a single 150 mg oral dose of fluconazole 2. Systemic candidiasis, including candidemia, disseminated candidiasis, and other invasive Candida infections (peritoneal, endocardial, pulmonary, urinary tract, etc.): The usual dose of this medicine is 400 mg once on the first day, followed by 200 mg once daily from the next day. The dose may be increased to 400 mg once daily according to the patient's response. The duration of treatment should be determined according to clinical response and medical judgment. 3. Cryptococcal meningitis and cryptococcosis at other sites: The usual dose of this medicine is 400 mg once on the first day, followed by 200-400 mg once daily from the next day. The duration of treatment is determined by clinical and mycological response, but treatment should usually continue for at least 6 ~ 8 weeks. 4. To prevent recurrence of cryptococcal meningitis in patients with AIDS, administer 200 mg of this medicine once daily indefinitely after the patient has completed primary treatment. 5. Prevention of fungal infections in immunocompromised patients at risk of fungal infection due to neutropenia caused by cytotoxic chemotherapy, radiation therapy, or bone marrow transplantation: Administer 50-400 mg of this medicine once daily according to the patient's risk of fungal infection. A dose of 400 mg once daily is recommended for patients at very high risk of systemic fungal infection, such as those with severe neutropenia or an expected prolonged period of neutropenia, as in bone marrow transplantation. In these patients, administer 400 mg starting 5-6 days before the expected onset of neutropenia, and continue 400 mg for 1 week after the neutrophil count has increased to 1,000 cells/mm3 or more. 6. For onychomycosis, administer 150 mg once weekly until the fingernails or toenails have regrown (until new, uninfected nails have grown). It usually takes 3-6 months for new fingernails to grow and 6-12 months for toenails; growth rate may vary among individuals according to age. In some cases, fingernails or toenails may remain damaged after successful treatment with long-term administration. For cutaneous fungal infections, including athlete's foot (tinea pedis), tinea corporis, jock itch (tinea cruris), and cutaneous candidiasis: The usual dose of this medicine is 50 mg once daily or 150 mg once weekly for 2-4 weeks. However, treatment of athlete's foot may need to continue for 6 weeks, depending on the course of the disease. For tinea versicolor, administer 50 mg once daily for 2-4 weeks. ○ Elderly patients If renal function is normal, administer the usual adult dose. In patients with renal impairment (creatinine clearance 50 mL/min or less), reduce the dose or extend the dosing interval. ○ Patients with renal impairment This medicine is excreted mainly in the urine unchanged. Dose adjustment is not necessary when administering a single dose. If multiple doses are required, administer the usual dose only on the first day of treatment and adjust the dose from the next day as follows. Creatinine clearance (mL/min) > 50: 100 % of the usual dose ≤50 (not on dialysis): 50% of the usual dose Patients on hemodialysis: 100% of the usual dose after each hemodialysis session For patients receiving hemodialysis, administer 100% of the usual dose after each hemodialysis session. On days when dialysis is not performed, administer a reduced dose according to creatinine clearance.

This drug is an azole antifungal agent and should not be administered to certain patients. Patients allergic to this drug or similar drugs, as well as pregnant or possibly pregnant women, and breastfeeding women should not use this drug. Additionally, it should be avoided in combination with certain medications due to the risk of severe side effects. This drug contains lactose, so patients with lactose intolerance or related genetic disorders should not take it. This drug should be administered cautiously in patients with impaired renal or liver function, heart disease, or at risk of arrhythmia. Patients with a history of drug hypersensitivity should also be cautious. This drug may affect liver function, so regular liver function tests should be conducted to monitor the condition. Generally, this drug is well tolerated, but various side effects such as blood abnormalities, allergic reactions, neurological symptoms, gastrointestinal disturbances, liver damage, and skin rashes may occur rarely. Particularly, due to the risk of liver toxicity or cardiac arrhythmia, you should consult medical professionals immediately if any abnormal symptoms occur. This drug has many drug interactions, requiring dose adjustments or monitoring when used in combination. Special caution is needed when used with medications affecting the heart, anticoagulants, certain antibiotics, anticonvulsants, immunosuppressants, and calcium channel blockers. You should inform your doctor or pharmacist about all medications you are currently taking to check for interactions. During pregnancy, the use of this medication should be avoided, especially in the early stages of pregnancy, as the risk of miscarriage or congenital malformations may increase. Women of childbearing age should ensure effective contraception during and after the use of this drug for a certain period. Breastfeeding is also discouraged as this drug is excreted into breast milk. Safety in infants under 6 months of age has not been established, thus it should only be used cautiously when absolutely necessary. Caution is required when driving or operating machinery, as this medication may cause dizziness or seizures. In case of overdose, hallucinations or abnormal behaviors may occur, and immediate medical attention should be sought. This drug is primarily excreted in urine, so adequate hydration and, if necessary, hemodialysis may be helpful.

Agranulocytosis, leukopenia, neutropenia, thrombocytopenia, anaphylaxis, angioedema, hypertriglyceridemia, hypercholesterolemia, hypokalemia, insomnia, drowsiness, headache, seizures, dizziness, sensory disturbances, taste disturbances, tremors, vertigo, Torsade de pointes, QT prolongation, abdominal pain, diarrhea, nausea, vomiting, dyspepsia, bloating, dry mouth, increased ALT, increased AST, increased serum alkaline phosphatase, cholestasis, jaundice, increased bilirubin, hepatotoxicity, liver failure, hepatocellular necrosis, hepatitis, hepatocellular damage, rash, itching, urticaria, increased sweating, drug rash, toxic epidermal necrolysis, Stevens-Johnson syndrome, acute generalized exanthematous pustulosis, exfoliative dermatitis, facial edema, hair loss, drug reactions with eosinophilia and systemic symptoms, myalgia, fatigue, lethargy, weakness, fever, adrenal insufficiency, hallucinations, aggressive behavior

This drug may be sensitive to air or moisture, so it must be stored in a tightly closed container. The storage temperature should be maintained between 1 degree and 30 degrees Celsius (room temperature). This will help preserve the drug's effectiveness safely.

Appearance

Pink rectangular tablet

Package unit

30 tablets/bottle