Enphed Tablet 0.5 mg (Entecavir)

Adult dose

This medicine should be taken orally on an empty stomach (2 hours after a meal or at least 2 hours before a meal). Take 0.5mg of entecavir orally once daily. Patients aged 16 years or older with lamivudine resistance, that is, patients who have experienced persistent replication of hepatitis B virus despite lamivudine treatment or who have lamivudine-resistant mutations: Take 1mg of entecavir once daily on an empty stomach. Patients with renal failure: Adjust the dose as follows in patients with creatinine clearance below 50mL/min, including patients receiving hemodialysis or continuous ambulatory peritoneal dialysis (CAPD). Creatinine clearance (mL/min) ≥ 50: entecavir dose 0.5 mg once daily, entecavir dose in patients with lamivudine resistance 1 mg once daily Creatinine clearance (mL/min) 30 - <50: entecavir dose 0.25 mg a once daily or 0.5 mg every 48 hours, entecavir dose in patients with lamivudine resistance 0.5 mg once daily or 1 mg every 48 hours Creatinine clearance (mL/min) 10 - <30: entecavir dose 0.15 mg a once daily or 0.5 mg every 72 hours, entecavir dose in patients with lamivudine resistance 0.3 mg a once daily or 1 mg every 72 hours Creatinine clearance (mL/min) <10, hemodialysis b or CAPD: entecavir dose 0.05 mg a once daily or 0.5 mg every 7 days, entecavir dose in patients with lamivudine resistance 0.1 mg a once daily or 1 mg every 7 days a: Use of the oral solution is recommended for doses below 0.5mg. b: If administered on a hemodialysis day, administer this medicine after the hemodialysis session.

This medication is used to treat liver disease and is specifically prescribed for patients with chronic hepatitis B virus infection. This drug can affect liver function, so patients with liver dysfunction should be especially cautious. In severe cases, side effects such as lactic acidosis and fatty liver may occur, which can be particularly dangerous in women and obese patients. During treatment, regular liver function tests should be conducted, and if liver dysfunction is detected, the medication may need to be temporarily discontinued. Also, abruptly stopping this medication may cause a rapid worsening of hepatitis B, so it should be tapered according to the physician's instructions, and liver function should be closely monitored even after discontinuation. This drug is not recommended for use in patients with untreated HIV infection, and an HIV antibody test should be conducted beforehand. It should not be administered to patients with hypersensitivity to this drug or genetic issues such as lactose intolerance. Patients with impaired renal function, particularly those undergoing hemodialysis or peritoneal dialysis, need dose adjustments, and liver transplant recipients must carefully monitor renal function. Common side effects include headache, fatigue, dizziness, nausea, etc., and rarely, serious hepatotoxicity or lactic acidosis may occur. Taking the medication with food may reduce absorption, so it is advisable to take it on an empty stomach. This drug is primarily excreted through the kidneys, so caution is needed when used with other medications that can affect renal function. During pregnancy, there may be risks to the fetus, so it should be used cautiously only when necessary, and nursing should be discontinued during treatment. It is also available for children and elderly patients, but dose adjustments and precautions are necessary based on renal function. In case of overdose, as there is no specific antidote, appropriate supportive care should be provided based on symptoms, and some can be removed through hemodialysis. The drug has been reported as possibly carcinogenic in animal studies, but its effects in humans are unclear. Store this medication out of reach of children, avoiding direct sunlight, and at room temperature.

liver dysfunction, headache, fatigue, dizziness, nausea, diarrhea, dyspepsia, vomiting, vertigo, drowsiness, insomnia, anaphylactic reactions, increased aminotransferases, hair loss, rash, upper abdominal pain, heartburn, itching, chest pain, constipation, abdominal pain, lower back pain, abdominal discomfort, runny nose, hematuria, thrombocytopenia, hyperglycemia, diabetes, hepatic neoplasm, intra-abdominal hemorrhage, ascites, portal hypertension with gastrointestinal disorders, gastrointestinal bleeding, cholangitis, hepatic encephalopathy, septal deviation, sepsis, eyelid skin disorders, gastric angioma, chronic sinusitis, abdominal pain, rash, unpleasant taste, neutropenia

This medication should be stored in a sealed container to prevent air exposure, ideally at a temperature between 15 to 30 degrees Celsius. This will help maintain the effectiveness of the drug over time.

Appearance

White to grayish-white, triangular film-coated tablet

Package unit

10 tablets/blister X 3