Prezista 600 mg (Darunavir Ethanolate)

Adult dose

This medicine must be administered concomitantly with a low dose of ritonavir (pharmacokinetic enhancer). Therefore, consult the prescribing information for ritonavir before starting concomitant administration of this medicine and ritonavir. Patients starting treatment with this medicine should not change the dose or discontinue treatment without a physician's instructions. Adults: The recommended dose of this medicine is 600mg twice daily, taken with ritonavir 100mg twice daily and food. The type of food does not affect darunavir exposure. Hepatic impairment: No dosage adjustment is necessary in patients with mild or moderate hepatic impairment. There are no data regarding the use of darunavir/ritonavir in patients with severe hepatic impairment. Therefore, darunavir/ritonavir is not recommended in patients with severe hepatic impairment. Renal impairment: No dosage adjustment is necessary in patients with moderate renal impairment. There are no pharmacokinetic data in HIV-1-infected patients with severe renal impairment or end-stage renal disease.

Child dose

Pediatric patients: The safety and efficacy of darunavir/ritonavir have not been established in pediatric patients.

This medication should not be used in conjunction with certain specific drugs, and it should not be taken by patients with severely impaired liver function or those who are hypersensitive to this drug. Since it can put stress on the liver, patients with chronic hepatitis or liver dysfunction should use it with caution and undergo regular liver function tests before and during treatment. This medication must be taken with the drug ritonavir; taking it alone may reduce its effectiveness. When used in combination with certain drugs, variations in drug concentration may lead to side effects or reduced therapeutic effect, so it is imperative to consult healthcare professionals if other medications are being taken. Common side effects may include diarrhea, headaches, and abdominal pain, while rare but serious adverse reactions such as severe skin rashes, hepatitis, or pancreatitis can also occur. Particular caution is required for patients allergic to sulfonamide derivatives. This medication may alter blood glucose and lipid levels, so patients with diabetes or dyslipidemia should regularly monitor their condition. Immune reconstitution syndrome, an immune system hypersensitivity reaction, may occur, so any unusual symptoms that arise early in treatment should be promptly reported to healthcare professionals. Symptoms such as dizziness may occur during driving or operating machinery, so caution is advised. While this drug is used for the treatment of HIV infection, it cannot completely prevent the transmission of HIV, thus safe lifestyle practices and preventative measures should be observed.

Hepatitis, acute hepatitis, cytolytic hepatitis, liver dysfunction, liver damage, diarrhea, headache, abdominal pain, laboratory abnormalities, nausea, vomiting, angioedema, pruritus, rash, Stevens-Johnson syndrome, urticaria, myalgia, osteonecrosis, decreased appetite, diabetes mellitus, asthenia, fatigue, drug hypersensitivity reaction, immune reconstitution syndrome, abnormal dreams, acute pancreatitis, dyspepsia, bloating, pruritus, gynecomastia, hypertriglyceridemia, hypercholesterolemia, increased liver enzymes, hyperglycemia, increased low-density lipoprotein, increased pancreatic enzymes, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS), acute generalized exanthematous pustulosis, crystalline kidney disease, fat redistribution, rhabdomyolysis, appetite loss, asthenia, fatigue, headache, increased liver enzymes, hypercholesterolemia, hyperglycemia, hypertriglyceridemia, immune reconstitution syndrome, increased low-density lipoprotein, nausea, increased pancreatic enzymes, rash, Stevens-Johnson syndrome, vomiting, osteonecrosis, increased bleeding in hemophilia patients, dizziness

This medication may be sensitive to air or humidity, so it should be stored in a tightly sealed container. The storage temperature should ideally be maintained between 1 and 30 degrees Celsius. This will help maintain the effectiveness of the medication over time.

Appearance

An orange oval film-coated tablet with '600MG' engraved on one side and 'TMC' on the other side

Package unit

60 tablets/bottle