Ketrazine Liquid (Levocetirizine Hydrochloride)

Adult dose

Adults: administer orally once daily 5 mg (10 mL as liquid form), regardless of meals. Adult patients with renal impairment should adjust the dose according to renal function (estimated glomerular filtration rate (eGFR)). - Normal renal function (≥ 90 mL/min): 5 mg once daily - Mild renal impairment (60-<90 mL/min): 5 mg once daily - Moderate renal impairment (30-<60...

Child dose

Children over 6 years: administer orally once daily 5 mg (10 mL as liquid form), regardless of meals. Children between 2 and under 6 years: administer 1.25 mg (2.5 mL as liquid form) once.

This medication should not be used in patients with hypersensitivity to certain components or those allergic to hydroxyzine or piperazine derivatives. It is also advisable for patients with end-stage renal disease or those undergoing dialysis to avoid taking this medication. Do not administer to infants under 1 year of age, and children under 6 years old should use the liquid form instead of tablets. The liquid formulation contains maltitol, so patients who are congenitally intolerant to fructose should avoid taking it. Patients with renal or liver function problems, as well as the elderly, should use this medication cautiously as it may remain in the body for long periods leading to side effects. This medication may cause central nervous system symptoms such as drowsiness, headache, and dizziness, thus caution is needed when driving or operating machinery. Gastrointestinal symptoms such as dry mouth, dyspepsia, abdominal pain, and diarrhea may also occur. Rare cardiovascular adverse effects such as increased heart rate or arrhythmias, hypertension may occur as well. Blood-related issues or allergic reactions, skin rashes, itching, and blurred vision have also been reported. For pregnant women, the safety for the fetus is unclear, so it should be used with caution after consulting a doctor. Breastfeeding mothers should also be cautious since this medication may be passed to breast milk and affect the baby. This medication can enhance sedative effects when taken with alcohol or antidepressants, so co-administration is not recommended. Patients with epilepsy or those at risk of seizures should be careful as their symptoms may worsen after taking this medication. Before taking this medication, it is advisable to stop taking it 3-5 days prior to planning clinical tests such as allergy testing. In the event of overdose, symptoms such as drowsiness or restlessness may appear; there is no specific antidote, so treatment should be symptomatic. Since it is difficult to remove this medication through dialysis, appropriate management in a hospital setting is necessary in case of overdose.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, anaphylaxis, angioedema, severe rash with high fever, blisters, skin peeling, pain in the oral/ocular mucosa, yellowing of the skin or eyes (jaundice), severe overall lethargy, sudden and severe headache, seizures, confusion, visual disturbances, paralysis, significantly reduced urination, severe swelling body-wide and increased blood pressure

Mild side effects

• Drowsiness
• fatigue
• headache
• numbness
• restlessness
• lethargy
• tiredness
• dizziness
• heaviness of the head
• excitement

This medication is sensitive to light, so it should be stored in a container that prevents light exposure. Additionally, it should be kept at room temperature between 1 and 30 degrees Celsius to maintain its effectiveness.

Appearance

Colorless transparent solution in a plastic bottle

Package unit

500 milliliters/bottle