Vancokit Injection

Adult dosage

For vancomycin, administer 500mg (activity) IV every 6 hours or 1g (activity) IV every 12 hours. For oral administration, 500-2000mg should be divided and given 3-4 times daily for 7-10 days. The total daily dose should not exceed 2g. The injection solution should be administered IV as a drip infusion over more than 60 minutes or, if intermittent infusion is difficult, slowly over more than 24 hours.

Children's dosage

Administer intravenously 10mg (activity) per kg of body weight every 6 hours. For infants, administer intravenously 10-15mg (activity) per kg of body weight every 12 hours. For infants and newborns, an initial dose of 15mg per kg of body weight is recommended.

This drug should not be used in patients who have had severe allergic reactions or shock in the past due to this drug. Additionally, it should not be administered to patients who have a history of allergic reactions to this drug or to peptide and aminoglycoside antibiotics. Patients with symptoms of deafness or a past history of hearing loss due to peptide or aminoglycoside antibiotics should not be treated, but in unavoidable situations, it should be used very cautiously. Patients with poor kidney function may experience delayed excretion of this drug, leading to increased blood concentration, so blood levels should be monitored frequently and administered cautiously. Caution is also needed for patients with liver dysfunction, as it may worsen liver function. Dosing should be particularly prudent for elderly patients, premature infants, and newborns as they have underdeveloped or impaired kidney function. This drug can affect hearing and the balance system, so patients with damage to the vestibular apparatus or cochlea should be careful. During administration, there may be severe allergic reactions like shock or anaphylaxis due to central nervous system anomalies, so patients should be closely observed, and if any abnormal symptoms appear, administration should be stopped immediately and appropriate treatment initiated. Gastrointestinal side effects such as diarrhea, nausea, vomiting, or abdominal pain may occur infrequently. Hematologic side effects such as reduction in red blood cells, white blood cells, and platelets may occur, but often resolve upon stopping treatment. Central nervous system effects such as dizziness, tinnitus, and hearing loss may appear, so regular hearing tests should be performed, and consideration should be given to stopping treatment if any abnormal symptoms arise. Liver function tests may show elevated levels of bilirubin, AST, ALT, and regular checks should be performed, and administration should be stopped if abnormalities present. Kidney function tests may show increased BUN and creatinine levels, so periodic tests should be done, and if abnormalities arise, dosage should be adjusted or administration stopped. Serious skin reactions such as severe dermatitis, bullous dermatitis, Stevens-Johnson syndrome may occur, so any skin changes should be reported and treated immediately. Hyperreactivity may present with symptoms such as rash, shortness of breath, hypotension similar to anaphylaxis, so close monitoring is required, and a slow administration rate is safer. Rapid injection of this drug may cause flushing or pain in the face and body, muscle cramps, etc., so it should be infused slowly over at least 60 minutes. Long-term use may lead to resistant bacteria, so administering it only for the minimum necessary duration based on susceptibility testing is recommended. Pseudomembranous colitis caused by Clostridium difficile may occur, so if symptoms of diarrhea, abdominal pain, or fever do not improve, administration should be stopped immediately. To prevent hearing damage, regular hearing checks are recommended, and assessments of kidney and liver function should be done regularly. Pregnant or breastfeeding women should be aware of potential effects on the fetus or newborn, so the decision to administer should only be made after consulting a physician, and breastfeeding should be avoided or stopped during administration. Pediatrics, especially premature infants and newborns, should be administered very cautiously due to immature kidney function, which may result in elevated blood levels. Elderly patients frequently have reduced kidney function, so kidney function tests should be performed before and during treatment, and dosage should be adjusted as necessary. In cases of overdose, acute renal failure or hearing damage can occur, so immediate professional treatment is required, as this drug is not easily removed by dialysis and may require special treatment. This drug can cause tissue damage and pain when administered intramuscularly, so it should only be given intravenously. Rapid injection at high concentrations may lead to serious side effects such as thrombotic phlebitis, hypotension, or cardiac arrest, so it's safer to dilute it and administer it slowly. This drug can become unstable when mixed with other alkaline solutions or beta-lactam antibiotics, so do not mix them together and give them with appropriate intervals. Before use, inspect the solution visually for discoloration or particulate matter, and do not use if abnormalities are found during packaging or the dissolving process.

Serious side effects

Shock, anaphylactic symptoms, hives, chest tightness, difficulty breathing, cold sweats, pallor, severe allergic reactions, exfoliative dermatitis, bullous dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, severe skin reactions, hypotension, wheezing, breathing difficulties, severe skin reactions (TEN, SJS, DRESS, AGEP, LABD, etc.), skin rash (including exfoliative dermatitis), mucosal lesions and blisters, jaundice

Mild side effects

• Loose stools
• diarrhea
• nausea
• vomiting
• abdominal pain
• reduction in red blood cells
• white blood cells
• platelets
• increased eosinophils
• dizziness

This drug should be stored in a sealed container to prevent air from entering and kept at temperatures between 1 degree and 30 degrees Celsius. Proper storage maintains the drug's effectiveness and safety.

Appearance

A kit injection that consists of a colorless transparent glass vial containing a white lump or powder, and a transparent polyethylene container with a dissolving agent to be used when mixed.

Package unit

1 kit (1 vial + 1 dissolving agent) × 10