Neuronnin Capsule 300 mg (Gabapentin)

Adult dose

Epilepsy — Monotherapy and adjunctive therapy in patients 13 years of age and older To achieve a maintenance dose of 900 mg/day as gabapentin, titrate the dose over the first 3 days of treatment as follows. Day 1: Administer one 300 mg capsule of this drug once daily, or one 100 mg capsule of this drug 3 times daily (gabapentin 300 mg/day) Day 2: Administer one 300 mg capsule of this drug twice daily, or two 100 mg capsules of this drug 3 times daily (gabapentin 600 mg/day) From Day 3: Administer one 300 mg capsule of this drug 3 times daily, or three 100 mg capsules of this drug 3 times daily (gabapentin 900 mg/day) Alternatively, as a starting dose, one 300 mg capsule of this drug may be administered 3 times daily (gabapentin 900 mg/day). The dose may be increased to 1,200 mg/day as gabapentin, and the total daily dose must not exceed 2,400 mg as gabapentin. (There are insufficient data on the safety and efficacy of doses exceeding 2,400 mg/day as gabapentin.) The duration of treatment should be determined according to clinical need. Long-term treatment is generally required for epilepsy. Although there is no evidence of a rebound phenomenon (increased frequency of epileptic seizures due to sudden discontinuation of treatment), sudden discontinuation of antiepileptic drugs in patients with epilepsy may cause status epilepticus. If treatment with this drug is to be discontinued, or if it is to be administered concomitantly with another antiepileptic drug, the change should be made gradually over at least 1 week. Neuropathic pain — Adults (18 years of age and older) To achieve a maintenance dose of 900 mg/day as gabapentin, titrate the dose over the first 3 days of treatment as follows. Day 1: Administer one 300 mg capsule of this drug once daily, or one 100 mg capsule of this drug 3 times daily (gabapentin 300 mg/day) Day 2: Administer one 300 mg capsule of this drug twice daily, or two 100 mg capsules of this drug 3 times daily (gabapentin 600 mg/day) From Day 3: Administer one 300 mg capsule of this drug 3 times daily, or three 100 mg capsules of this drug 3 times daily (gabapentin 900 mg/day) Alternatively, as a starting dose, one 300 mg capsule of this drug may be administered 3 times daily (gabapentin 900 mg/day). If necessary, the dose may be increased to 1,800 mg/day as gabapentin within one week, and the total daily dose must not exceed 3,600 mg as gabapentin. The total daily dose of this drug should be divided into 3 doses. The safety and efficacy of treatment for neuropathic pain for more than 5 months have not been evaluated. Debilitated patients In debilitated patients with low body weight or patients after transplantation, the gabapentin dose should be increased in 100 mg increments. Elderly patients Dose adjustment may be required due to age-related decline in renal function (see table). Patients with renal impairment (creatinine clearance ≤80 mL/min) or patients receiving hemodialysis Dose adjustment is required based on the following table. Dosage for patients with renal impairment: Creatinine clearance ≥80 mL/min: Total daily dose 900∼2,400 mg/day Creatinine clearance 50∼79 mL/min: Total daily dose 600∼1,800 mg/day Creatinine clearance 30∼49 mL/min: Total daily dose 300∼900 mg/day Creatinine clearance 15∼29 mL/min: Total daily dose 150b∼600 mg/day Creatinine clearance <15 mL/min: Total daily dose 150b∼300 mg/day a: The total daily dose should be divided into 3 doses. b: 3 × 100 mg should be administered every 2 days. For patients with creatinine clearance below 15 mL/min, the dose should be reduced in proportion to creatinine clearance. Dosage for patients on hemodialysis Initial dose: 300∼400 mg of gabapentin is recommended. Maintenance dose: Administer 200∼300 mg of gabapentin after 4 hours of hemodialysis, and do not administer this drug on days when hemodialysis is not performed. Method and duration of administration This drug should be swallowed whole with sufficient fluid and may be taken with or without food. When administered 3 times daily, care should be taken to ensure that the interval between doses does not exceed 12 hours to prevent recurrence of seizures. If a dose of this drug is missed (12 hours or more have elapsed since the most recent dose), the physician should decide whether an additional dose should be administered to make up for it. When this drug is administered concomitantly with antacids containing magnesium or aluminum, it should be administered at least 2 hours after the antacid. This can substantially reduce the decrease in the bioavailability of this drug. The duration of treatment with this drug should be determined according to clinical need. If the dose of this drug is reduced, treatment is discontinued, or the patient is switched to another alternative drug, this should be done gradually over at least 1 week (a longer period may be needed at the prescriber's discretion). To reduce the main adverse reactions, such as somnolence, dizziness, fatigue, and ataxia, the first dose on the first day of treatment should be taken at bedtime.

Child dose

Adjunctive therapy for children aged 3 to 12 years Day 1: Administer gabapentin 10 mg per body weight (kg) Day 2: Administer gabapentin 20 mg per body weight (kg) From day 3: Administer gabapentin 30 mg per body weight (kg) If necessary, the dose may be increased to a maximum of 40 mg per body weight kg per day. The total daily dose of this medicine should be divided into 3 doses.

During the use of this medication, it is essential to carefully monitor for suicidal thoughts or behaviors, symptoms of depression, and any abnormal changes in mood or behavior. Abruptly stopping this medication can exacerbate seizures or lead to a continuous epileptic state; therefore, it must be gradually reduced under a physician's supervision. This medication can cause severe pancreatic disorders, such as pancreatitis; if symptoms such as persistent upper abdominal pain or vomiting occur, discontinue use immediately and consult healthcare professionals. Particularly in children and adolescents, there may be neuropsychiatric adverse reactions such as emotional instability, aggression, decreased concentration, and hyperactivity, so caution is warranted. Co-administration of this drug with central nervous system depressants, including narcotics, may lead to severe drowsiness, respiratory distress, and coma; thus, it should only be used at the minimum dose for short periods, with close monitoring by healthcare professionals. This drug should not be administered to patients with specific genetic problems, acute pancreatitis, or generalized tonic-clonic seizures. Patients with reduced renal function, the elderly, those with a history of psychiatric disorders, pregnant women or those of childbearing potential, and nursing mothers should be especially careful when using this medication and may require dosage adjustments. While taking this drug, side effects such as dizziness, drowsiness, ataxia, headache, nausea, vomiting, weight gain, visual disturbances may occur; if these symptoms persist, inform the healthcare provider. During pregnancy, this medication may affect the fetus, so if planning pregnancy or already pregnant, consult a physician before use, and nursing mothers should discontinue breastfeeding while taking this medication. This drug has the potential for dependence and abuse; therefore, patients with a history of substance abuse should use it with caution, and sudden discontinuation may lead to withdrawal symptoms such as anxiety, insomnia, nausea, and headache. While taking this medication, avoid driving or operating hazardous machinery, and do not mix with alcohol or other central nervous system depressants.

suicidal impulses, suicidal behavior, depression, emotional instability, hostility, abnormal thinking, hyperactivity, abdominal pain, low back pain, fatigue, fever, headache, viral infections, vasodilation, constipation, abnormal teeth, diarrhea, dyspepsia, increased appetite, thirst, nausea, vomiting, leukopenia, peripheral edema, weight gain, fractures, myalgia, amnesia, ataxia, confusion, impaired coordination, dizziness, dysphonia, insomnia, neurotic responses, nystagmus, drowsiness, abnormal thinking, tremor, single contraction, cough, pharyngitis, rhinitis, erosion, acne, itching, rash, amblyopia, diplopia, erectile dysfunction, weakness, lethargy, facial swelling, hypertension, abdominal distension, anorexia, gingivitis, purpura, arthralgia, hyperactivity, increased reflex activity, decreased reflex activity, absence of reflex activity, sensory abnormalities, anxiety, pneumonia, urinary tract infection, vision problems, viral infections, bronchitis, respiratory infection, dehydration, infectious mononucleosis, hepatitis, blood coagulation abnormalities, loss of signs, laryngeal neuralgia, sleepwalking, pseudocroup, hoarseness, injuries from accidents, cold syndrome, pain, dry mouth, gait disturbances, confusion, sensory impairment, tremors, vertigo, dyspnea, rash, myasthenia, apathy, facial edema, allergy, generalized edema, weight loss, chills, feelings of strangeness, lethargy, alcohol intolerance, hangover effects, hypotension, angina, peripheral vascular disorders, palpitations, tachycardia, migraine, noise, atrial fibrillation, heart failure, thrombophlebitis, myocardial infarction, cerebrovascular accident, pulmonary thrombosis, ventricular extrasystole, bradycardia, immature atrial contraction, pericardial friction, heart block, pulmonary embolism, hyperlipidemia, hypercholesterolemia, pericardial effusion, pericarditis, glossitis, gum bleeding, thirst, stomatitis, increased salivation, gastroenteritis, hemorrhoids, bloody stools, fecal incontinence, hepatomegaly, dysphagia, belching, pancreatitis, gastric ulcer, colitis, oral vesicles, tooth discoloration, angular cheilitis, sialadenosis, lip bleeding, esophagitis, hiatal hernia, hematemesis, rectitis, irritable bowel syndrome, rectal bleeding, esophageal spasm, hyperthyroidism, hypothyroidism, thyroid hypertrophy, hypoestrogenism, ovarian failure, epididymitis, testicular swelling, Cushingoid appearance, anemia, lymphadenopathy, thrombocytopenia, leukocytosis, lymphocytosis, non-Hodgkin lymphoma, prolonged bleeding time, tendinitis, arthritis, joint stiffness, joint swelling, benign Romberg test, costochondritis, osteoporosis, bursitis, contracture, syncope, dream disorders, aphasia, sensory impairment, intracranial hemorrhage, hypotonicity, paresthesia, incomplete paralysis, dystonia, hemiplegia, facial paralysis, delirium, cerebellar dysfunction, benign Babinski sign, reduced proprioception, subdural hematoma, apathy, hallucinations, decreased libido, restlessness, paranoia, depersonalization, dysphoria, hyperreactivity, suicidal impulses, mental disorders, chorea with athetosis, perioral movement disorders, brain diseases, neuritis, personality disorders, increased libido, organic inhibition, apraxia, fine motor coordination disorders, meningitis, local focal seizures, perceptual hypersensitivity, reduced motor function, mania, neurosis, hysteria, antisocial reactions, suicidal behavior, epistaxis, dyspnea, apnea, mucositis, aspiration pneumonia, hyperventilation, hiccups, laryngitis, nasal congestion, sinusitis, bronchospasm, hypoventilation, pulmonary edema, hair loss, eczema, dry skin, increased sweating, urticaria, hirsutism, seborrhea, cysts, herpes simplex, shingles, skin discoloration, skin papules, photosensitivity, leg ulcers, scalp seborrhea, psoriasis, epidermolysis, maceration, skin nodules, melanosis, skin necrosis, localized swelling, hematuria, voiding disorders, frequency, cystitis, urinary retention, incontinence, vaginal bleeding, amenorrhea, menstrual irregularities, menorrhagia, breast cancer, anovulation, ejaculation abnormalities, renal pain, leukorrhea, genital itching, kidney stones, acute renal failure, anuria, diabetes, nephritis, nocturia, pyuria, urgency, dysmenorrhea, mastalgia, testicular pain, hearing loss, ear pain, tinnitus, labyrinthitis, ear inflammation, taste loss, taste abnormalities, blepharospasm, eye fullness, eye itching, accommodation abnormalities, tympanic membrane perforation, sound hypersensitivity, visual fixation abnormalities, overflow tear, retinopathy, glaucoma, iritis, corneal disorders, lacrimal dysfunction, ocular atrophy, blindness, retinal degeneration, miosis, choroiditis, strabismus, Eustachian tube dysfunction, labyrinthitis, otitis externa, olfactory abnormalities, increased serum creatine phosphokinase, rhabdomyolysis, acute renal failure, urticaria, allergic reactions, anaphylaxis, angioedema, hyperglycemia, hypoglycemia, gynecomastia, chest pain, toxic epidermal necrolysis, eosinophilia, systemic symptoms accompanying drug rash, increased liver function test results, erythema multiforme, falls, generalized edema, gynecomastia, hallucinations, hepatitis, systemic reactions including hypersensitivity, hyponatremia, jaundice, loss of consciousness, chorea with athetosis, movement disorders, dystonia, glycogenic seizure syndrome, palpitations, pancreatitis, sexual dysfunction, Stevens-Johnson syndrome, thrombocytopenia, tinnitus, urinary incontinence, tongue paralysis, insomnia, nausea, pain, sweating, tremors, headache, abnormal sensations, lethargy

This medication is sensitive to air and moisture, so it must be stored in a tightly sealed container. It is essential to maintain a storage temperature between 1 and 30 degrees Celsius to preserve its effectiveness.

Appearance

Yellowish-brown hard capsule containing white or grayish-white powder

Package unit

30 capsules/bottle, 300 capsules/bottle