Seprosim Tablet (Cefuroxime Axetil)

Adult dose

For optimal absorption, take after a meal. Adults and children 12 years and older Most infections: Administer 250mg per dose, twice daily. Severe lower respiratory tract infections, pneumonia, severe infections, or suspected infections caused by less susceptible organisms: Administer 500mg per dose, twice daily. Urinary tract infections: Administer 250mg per dose, twice daily. Uncomplicated gonorrhea: Administer a single dose of 1g. Lyme disease: Administer 500mg per dose, twice daily, for 14 days (10~21 days). For treatment of infections caused by Streptococcus pyogenes (Group A beta-hemolytic), this drug should be administered for 7~10 days. Patients with renal impairment Creatinine clearance ≥ 30 mL/min/1.73m2 (T1/2 1.4 - 2.4 hours): No dose adjustment required (standard dose: 125mg-500mg per dose, twice daily) Creatinine clearance 10 - 29 mL/min/1.73m2 (T1/2 4.6 hours): Administer a standard single dose every 24 hours Creatinine clearance < 10 mL/min/1.73m2 (T1/2 16.8 hours): Administer a standard single dose every 48 hours Patients on hemodialysis (T1/2 2 - 4 hours): Administer an additional standard single dose at the end of each dialysis session

Child dose

Infants and children under 12 years, most infections: Administer 125mg per dose, twice daily. Children 2 years and older, otitis media, severe infections: Administer 250mg per dose, twice daily. Children under 12 years, Lyme disease: Administer 250mg per dose, twice daily, for 14 days (10~21 days). There is insufficient experience with use in infants under 3 months of age.

This drug should not be administered to patients with hypersensitivity to cephalosporin antibiotics. Patients with a history of hypersensitivity to penicillin or other beta-lactam antibiotics, patients with allergic dispositions, patients with severe renal impairment, patients who cannot take orally, elderly patients, and patients with poor general health should be given this drug with caution. This drug may generally cause mild and transient adverse reactions, with reports of skin rashes, urticaria, itching, headaches, dizziness, gastrointestinal disturbances, and elevated liver enzymes, among others. Severe skin reactions, blood abnormalities, hepatitis, or renal dysfunction may occur infrequently, and immediate consultation with medical personnel is necessary upon symptom onset. When administering this drug, susceptibility testing should be performed to prevent the development of resistant bacteria, using it only for the necessary minimum duration. Allergic reactions or shock symptoms may occur, so the patient's condition should be observed closely, and the administration should be stopped if adverse symptoms appear. Long-term use may lead to Candida overgrowth or pseudomembranous colitis, requiring careful monitoring. This drug may cause dizziness, so caution is necessary when driving or operating machinery. Caution should be exercised when using in conjunction with other drugs that may affect renal function, as this may increase the risk of renal impairment. Women who are pregnant or breastfeeding should consult their physician carefully before using this drug. Safety in infants under 3 months has not been established, so appropriate formulations should be selected for pediatric administration. Elderly patients may experience more adverse reactions due to decreased physiological function, so dosage and intervals should be adjusted, and they should be monitored closely. This drug may affect some clinical test results, so patients should inform medical personnel of its use when undergoing tests. In cases of overdose, severe central nervous system stimulation symptoms such as seizures may occur, requiring caution; blood dialysis or peritoneal dialysis can be used to reduce drug levels if necessary. Keep this drug out of the reach of children and store medications in their original containers to prevent degradation of quality or misuse.

• Candidiasis hyperproliferation
• eosinophilia
• positive Coombs test
• thrombocytopenia
• leukopenia
• neutropenia
• anemia
• decreased hemoglobin
• decreased hematocrit
• hemolytic anemia

This drug should be stored in a tightly sealed container to prevent exposure to air or moisture. It is best to keep the storage temperature between 1 degree and 30 degrees Celsius (room temperature).

Appearance

White rectangular film-coated tablets

Package unit

50 tablets (10 tablets/PTPX5)