Metidin Tablets (Cimetidine)

Adult dosage

As cimetidine, take 400 mg orally twice a day (in the morning and at bedtime) or 800 mg once daily (at bedtime). Also, take 300 mg orally four times a day (after meals and at bedtime). The dose may be increased to a total of 1.6 g by taking 400 mg orally four times a day (after meals and at bedtime). For the improvement of gastric mucosal lesions, during acute gastritis and acute exacerbation of chronic gastritis, take 200 mg orally twice a day or administer 400 mg once daily.

Children's dosage

Administer orally in divided doses of 20-40 mg per kg of body weight per day.

This medication may contain glass fragments when administering a glass ampoule injection, requiring special care, especially for children and the elderly. It is safest for patients with hypersensitivity to this medication or those taking dofetilide not to use it. Patients with reduced kidney or liver function, a history of drug hypersensitivity, the elderly, children under 19 years old, and patients undergoing hemodialysis should use this medication with caution, as symptoms of gastric cancer may be concealed; therefore, administration should be decided after confirming malignancy. This medication contains specific dyes, so patients with allergies to these components should be cautious. During treatment, abnormalities in blood test results may appear, so if you experience systemic fatigue or bleeding symptoms, you should get tested immediately and discontinue if necessary. Regular tests are required as liver function abnormalities or symptoms of reduced kidney function may appear. Rarely, allergic reactions such as shock or anaphylaxis, skin rash may occur; thus, use should be immediately stopped if these symptoms appear. Symptoms such as gynecomastia, increased milk secretion, erectile dysfunction, and other endocrine abnormalities may also occur, so careful observation is required. Various side effects related to gastrointestinal symptoms or central nervous system abnormalities, and circulatory system abnormalities have been reported; if any abnormal symptoms arise, consult with healthcare professionals. This medication interacts with many other drugs, so dosage adjustment or administration intervals may be necessary depending on the type of medication taken concurrently. Pregnant or nursing women should consult with a physician before using this medication as it may affect the fetus or newborn. Caution should be exercised when administering this medication to children or the elderly, especially in the elderly, as reduced kidney function may increase the medication concentration, thus requiring a dosage adjustment. In cases of overdose, severe side effects such as respiratory depression may occur; therefore, emergency treatment must be sought immediately. When used as an injection, rapid intravenous injection may cause arrhythmias or hypotension, so it should be administered slowly.

Serious side effects

Systemic fatigue, weakness, subcutaneous bleeding, mucosal bleeding, fever (initial symptoms of hematologic abnormalities), jaundice, shock, anaphylaxis-like reactions, systemic rash, difficulty breathing, hypersensitivity vasculitis, rash, altered consciousness, seizures, confusion state (anxiety, psychosis, depression, excitement, hallucinations, disorientation), Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell syndrome), epidermal necrosis, erythema multiforme, exfoliative dermatitis, systemic desquamative erythema edema,

Mild side effects

• Leukopenia
• agranulocytosis
• thrombocytopenia
• pancytopenia
• aplastic anemia
• hepatitis
• elevated AST
• ALT
• interstitial seizures
• acute renal failure

This medication should be stored in a tightly sealed container in a well-ventilated area, at a temperature between 1 degree and 30 degrees Celsius. Storing it in this manner helps to maintain the medication's efficacy and prevent degradation.

Appearance

Pale green round film-coated tablet

Package unit

For domestic use - 500 tablets/bottle, for export - 100 tablets/box [(10 tablets/PTP x 10)]