Curasil Tablet 125 mg (Terbinafine Hydrochloride)

Adult dose

As terbinafine, administer 125 mg once, twice a day, or 250 mg once daily. The treatment duration varies by condition as follows: 1) Dermatophytosis Tinea pedis (interdigital type, plantar type/mocha type): 2–6 weeks Tinea corporis: 2–4 weeks Tinea cruris: 2–4 weeks 2) Onychomycosis Typically administered for 6 weeks to 3 months. If the infection is in the fingernail or a relatively small toe, or if the patient is younger, the treatment duration may be reduced to less than 3 months. The treatment duration for toenail infections is typically sufficient at 3 months, but in some patients, it may take 6 months or longer. If the patient has slow nail growth, the treatment duration may be prolonged. 2. Pediatric: Administer to children over 2 years of age. There is insufficient experience for administering to patients under 2 years, so it is not recommended. Tinea capitis: 4 weeks. Tinea capitis mainly occurs in children. To prevent recurrence of infection, treatment should be conducted for a regularly defined period. 1) Weight under 20 kg (under 5 years): administer 62.5 mg once daily. Due to a lack of experience, the decision to administer should consider the benefits and risks of treatment. 2) Weight 20–40 kg (5–12 years): administer 125 mg once daily. 3) Weight over 40 kg (over 12 years): administer 250 mg once daily. 3. Patients with renal impairment In patients with a creatinine clearance rate of less than 50 mL per minute, reduce the daily dose by half.

Child dose

Administer to children over 2 years of age. Tinea capitis: 4 weeks 1) Weight under 20 kg (under 5 years): administer 62.5 mg once daily. 2) Weight 20–40 kg (5–12 years):

This medication should generally not be used in patients with chronic liver disease or active liver disease. Liver function tests must be performed before administration, and regular liver function tests should be conducted during treatment. If symptoms of liver dysfunction appear, stop taking this medication immediately and consult a physician. It is not recommended for patients with blood disorders, severe renal impairment, nursing women, or infants under 2 years of age. Use with caution in patients with decreased renal function, elderly patients, or underweight children. Discontinue use immediately if severe rash or allergic reactions occur. This medication may affect the liver and kidneys, so regular liver function and blood tests should be performed while on this medication. Dizziness or drowsiness may occur with this medication, so caution should be taken when driving or operating machinery. Interactions with other medications may occur, so be sure to inform your doctor or pharmacist about any other medications you are taking. Women who are pregnant or could become pregnant should consult a physician before taking this medication. Nursing women should discontinue breastfeeding while on this medication. Safety in children, particularly infants under 2 years of age, has not been established, and therefore it is not recommended. In the case of overdose, symptoms such as headache, nausea, abdominal pain, and dizziness may occur, and prompt medical attention should be sought. Store this medication out of the reach of children and keep it in a closed container away from direct sunlight at room temperature.

Serious side effects

Liver failure, hepatitis, cholestasis, jaundice, symptoms of impaired liver function (persistent nausea, loss of appetite, fatigue, vomiting, right upper abdominal pain, jaundice, dark urine, soft stools), Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, erythema multiforme, toxic skin rash, exfoliative dermatitis, blistering dermatitis, rhabdomyolysis, hypotension, respiratory distress, chest tightness, anaphylactic reactions (including angioedema and systemic lupus erythematosus)

Mild side effects

• Rash
• skin itching
• fever
• nausea
• vomiting
• loss of appetite
• fatigue
• leukopenia
• anemia
• photosensitivity reactions

Store this medication in a sealed container to avoid exposure to air or moisture. It is important to maintain a storage temperature between 1°C and 30°C. Proper storage will help preserve the effectiveness of the medication.

Appearance

White to off-white round tablets

Package unit

30 tablets/bottle