Stirid T-Ce 150 mg (Lamivudine)

Adult dose

Adults: The recommended dose is 150 mg twice daily or 300 mg once daily. If you wish to change the dosing schedule, follow the instructions below. 1) To change from twice-daily to once-daily dosing: After taking the last dose under the twice-daily regimen, wait approximately 12 hours before taking the dose for the once-daily regimen. Thereafter, take the medication once daily at 24-hour intervals. 2) To change from once-daily to twice-daily dosing: After taking the last dose under the once-daily regimen, wait approximately 24 hours before taking the medication according to the twice-daily regimen. Adults, adolescents, and pediatric patients weighing 25 kg or more with renal impairment: Clcr ≥ 30: Initial dose 300mg or 150 mg; maintenance dose 300 mg once daily or 150 mg twice daily 30 ＞ Clcr ≥15: Initial dose 150 mg; maintenance dose 100 mg once daily 15 ＞ Clcr ≥5: Initial dose 150 mg; maintenance dose 50 mg once daily 5 > Clcr: Initial dose 50 mg; maintenance dose 25 mg once daily * No additional dose is required after hemodialysis or peritoneal dialysis. Patients with hepatic impairment: In a study of patients with moderate to severe hepatic impairment, hepatic impairment did not have a significant effect on the pharmacokinetics of this drug. Therefore, no dose adjustment is necessary based on the degree of hepatic impairment.

Child dose

Adolescents and children weighing 25 kg or more: Administer 150 mg twice daily or 300 mg once daily. Weighing 20kg or more to less than 25kg: The recommended daily dose is 225 mg. Administer 1/2 tablet (75 mg) in the morning and 1 tablet (150 mg) in the evening, or 1 and 1/2 tablets (225 mg) once daily. Weighing 14kg or more to less than 20kg: The recommended daily dose is 150 mg. Administer 1/2 tablet (75 mg) twice daily or 1 tablet (150 mg) once daily. Children under 3 months of age: Data on the use of this drug are very limited. Children aged 3 months or older and weighing less than 25kg: There are insufficient data to recommend dose adjustment for this drug; however, adjustment of the dosing interval should be considered in pediatric patients with a creatinine clearance of less than 50 mL/min.

This drug should not be used alone and must be taken in conjunction with other antiretroviral drugs because resistance can easily develop with monotherapy. Serious liver problems such as lactic acidosis, hepatic enlargement, and fatty liver may occur during treatment with this drug, so if these symptoms are suspected, treatment should be discontinued immediately and medical attention sought. Patients co-infected with HIV and Hepatitis B virus may experience a rapid worsening of Hepatitis B if this medication is discontinued, so regular liver function tests should be performed even after discontinuation. If symptoms of pancreatitis appear, such as severe abdominal pain, nausea, or vomiting, the medication should be stopped immediately and consultation with healthcare professionals is required. Changes in body fat distribution, increased blood glucose and lipid levels may occur during treatment, necessitating regular check-ups, and appropriate treatment should be pursued for any abnormalities. Patients with allergies to this drug or its ingredients should not take it, and dose adjustments are required for those with moderate to severe renal impairment. Patients with a history of chronic liver disease or pancreatitis, and those undergoing treatment for chronic Hepatitis C should exercise special caution when taking this medication. During treatment, gastrointestinal symptoms such as nausea, vomiting, abdominal pain, diarrhea, as well as blood anomalies, elevated liver enzymes, muscle pains, and neurological symptoms may occur. Patients should inform healthcare professionals of any such symptoms. Pregnant women should only take this medication if the benefits of treatment outweigh the risks, particularly during the first three months of pregnancy. This drug may be excreted in breast milk, so women taking this medication are advised not to breastfeed to prevent HIV transmission to the baby. Elderly patients may have reduced renal function, so the dosage and administration interval should be adjusted for cautious administration. In case of overdose, no specific symptoms may present, but patients should be closely monitored and treated with dialysis if necessary. This drug should be kept out of reach of children, and storage in the original container is important to maintain quality. Long-term effects of this medication have not yet been fully established, hence careful management under the guidance of healthcare professionals is required during use.

Severe hepatomegaly accompanied by lactic acidosis and fat infiltration, pancreatitis, nausea, vomiting, abdominal pain, abdominal cramping, diarrhea, anorexia, dyspepsia, gastritis, abdominal bloating, elevated serum amylase, neutropenia, anemia, thrombocytopenia, aplastic anemia, erythrocytosis, pancytopenia, leukopenia, neutropenia, elevated liver enzymes (AST/ALT), hepatitis, arthralgia, myopathy, myalgia, rhabdomyolysis, mood disorders, dizziness, headache, insomnia, depression, anxiety, peripheral neuropathy, sensory disturbances, perceptual disturbances, cough, nasal symptoms, abnormal breath sounds, wheezing, elevated serum creatinine, cardiomyopathy, rash, alopecia, pruritus, body fat redistribution/accumulation, hypertriglyceridemia, hypercholesterolemia, insulin-dependent hyperglycemia, dehydration, hyperlactatemia, lactic acidosis, anaphylaxis, urticaria, insomnia, weight loss, weight dysregulation, fatigue, weakness, lymphadenopathy, splenomegaly, malaise, fever, esophagitis, dermatitis, hyperbilirubinemia, hypersensitivity, increased ALP, chest pain, lumbago, arthritis, hematuria, urolithiasis, nephralgia, abnormal semen, drowsiness

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture. Additionally, it is advisable to avoid temperatures that are too hot or too cold and to store at room temperature.

Appearance

White diamond-shaped film-coated tablets

Package unit

60 tablets/bottle