Gujuin Codeine Tablets

Adult dose

For codeine phosphate hemihydrate, the initial dose is 20 mg orally, three times a day. This dose can be taken up to four times a day with a minimum interval of 6 hours. The maximum daily dose must not exceed 240 mg. The dose may be adjusted appropriately according to symptoms.

Child dose

For codeine phosphate hemihydrate, the recommended daily dose is 30 to 60 mg, administered in divided doses every 6 hours. The recommended daily dose is based on body weight (0.5 to 1 mg/kg). The maximum daily dose is 240 mg.

This medication is metabolized in the liver and converted to morphine, so individual metabolic rates can vary, resulting in a rapid increase in morphine concentration in some cases, leading to serious side effects. If slow or shallow breathing, confusion, insomnia, constricted pupils, constipation, or decreased appetite occur during treatment, discontinue use immediately and consult a physician. Particularly, it is advisable for obese patients under 18 years old or individuals with obstructive sleep apnea or severe lung diseases not to use this drug. Care should be taken when using this drug in combination with other central nervous system depressants or alcohol, as it can lead to severe drowsiness, respiratory depression, coma, and even death. Patients with certain conditions such as acute respiratory depression, severe liver dysfunction, asthma attacks, hemorrhagic colitis, severe lung diseases, or seizure disorders should avoid using this medication as it may pose risks. Women who are pregnant or may become pregnant, as well as breastfeeding mothers, should not take this drug due to the potential harmful effects on infants through breast milk. Elderly patients or those with impaired kidney or liver function should use this medication cautiously, starting with a low dose. Long-term use of this drug may result in dependence, requiring gradual dose reduction under medical supervision if symptoms occur. Drowsiness or dizziness may arise during treatment, so it is advisable to avoid driving or operating hazardous machinery. In case of overdose, severe respiratory depression, decreased consciousness, heart issues, etc., may occur; immediate medical attention is required.

Serious side effects

Slow or shallow breathing, difficulty breathing, irregular breathing, apnea, severe respiratory depression, seizures, shock, acute or severe respiratory depression, increased carbon dioxide levels in the blood, cor pulmonale, acute asthma, status asthmaticus, severe liver dysfunction, heart failure secondary to chronic lung disease, seizure states (status epilepticus, tetanus, strychnine poisoning), acute alcohol intoxication, hypersensitivity (hives, severe swelling, chest tightness)

Mild side effects

• Confusion
• insomnia
• constricted pupils
• constipation
• decreased appetite
• drowsiness
• dizziness
• visual disturbance
• sweating
• nausea

This medication may be sensitive to light, so it should be stored in an opaque container that blocks light. Additionally, it should be stored in a sealed container to prevent air exposure, ensuring the drug's efficacy is maintained.

Appearance

White to yellowish round tablets

Package unit

100 tablets/box [10 tablets/PTP x 10]