Cramonex Tablets (Amoxicillin and Klavulanic Acid Potassium Combination (2:1))

Adult dose

The dosage of this medication should be considered based on the patient's age, weight, renal function, and severity of infection. To minimize potential gastrointestinal intolerance, it should be administered at the beginning of meals. The absorption of amoxicillin/klavulanic acid is optimized when administered at the start of meals. Adults and children aged 12 years or older or weighing 40 kg or more: Amoxicillin/klavulanic acid potassium at a single dose of 250 mg/125 mg, three times a day every 8 hours.

Child dose

Children aged 12 and older or weighing 40 kg or more should receive the same dosage as adults. Children with renal impairment should have their dosage reduced in the same manner as adults.

This medication is a beta-lactam antibiotic and should not be administered to patients with hypersensitivity to penicillins and cephalosporins. It can be dangerous for those with a history of anaphylaxis, Stevens-Johnson syndrome, or shock. It is advisable not to use this medication in patients with infectious mononucleosis or lymphocytic leukemia due to an increased risk of rash. Patients with a history of jaundice or liver dysfunction due to this medication or penicillins should avoid its administration to prevent the risk of recurrence. Caution is needed for patients with impaired liver function or severe renal impairment as elevated drug concentrations can worsen side effects. Patients with allergies, those receiving parenteral nutrition, the elderly, and those in poor general health are at risk of vitamin K deficiency and bleeding. Care should also be taken with severely vomiting or diarrhea patients as the drug may not be absorbed properly. This medication can cause gastrointestinal side effects such as diarrhea, vomiting, and abdominal pain, and in severe cases, may lead to pseudomembranous colitis or acute pancreatitis, so immediate medical consultation is required if symptoms arise. Liver function abnormalities may occur, so regular liver function tests are important during prolonged use. If there are any severe allergic reactions, such as skin rashes, urticaria, or Stevens-Johnson syndrome, the administration should be stopped immediately, and medical guidance should be followed. Rarely, there can also be blood disorders, renal function impairment, and central nervous system reactions, so any unusual symptoms should be reported immediately. This medication may interact with other drugs, so if you are taking any other medications, it is essential to inform your doctor or pharmacist. The use of this medication during pregnancy or breastfeeding should be carefully considered, especially avoiding its use in the first three months of pregnancy. It is not recommended for children under 12 years old or weighing less than 40 kg, and dosage adjustment and monitoring are necessary for the elderly due to a higher risk of side effects. In case of overdose, symptoms such as vomiting, diarrhea, rash, and convulsions may occur, so immediate medical attention is needed.

Serious side effects

Hives, severe swelling, chest tightness, difficulty breathing, cold sweat, paleness, severe rash with fever, blisters, skin peeling, pain in mucous membranes of mouth/eyes, severe skin reactions, shortness of breath or difficulty breathing, asthma attacks, respiratory distress accompanying cough and fever, jaundice (yellowing of skin or eyes), extreme lethargy, liver abnormalities (jaundice), sudden and severe headaches, thunderclap headache, seizures.

Mild side effects

• Diarrhea
• pseudomembranous colitis
• indigestion
• stomatitis
• gastritis
• glossitis
• black hairy tongue
• nausea
• vomiting
• loss of appetite

This medication should be stored in a tightly sealed container to prevent moisture, and during storage, a cool temperature between 1 degree and 25 degrees should be maintained. Avoid direct sunlight and do not place it in excessively hot or cold places.

Appearance

Elliptical film-coated tablets, white to nearly white

Package unit

80 tablets/box (8 tablets/PTP x 10), 100 tablets/box (10 tablets/PTP x 10)