Pervon Injection 30 mg (Polynate Calcium)

Key information summary

Efficacy & effects

This medication helps reduce the side effects of folate metabolism antagonists. It is also used to enhance treatment effects when combined with 5-Fluorouracil (5-FU) for the treatment of metastatic colorectal cancer. It is available in injection and tablet forms, allowing for administration according to the patient's condition. In summary, this medication is used to reduce the toxicity of folate metabolism antagonists and assist in the treatment of metastatic colorectal cancer.

Dosage

1. Methotrexate standard therapy: Administer 6-12 mg as a polyinate intramuscular injection every 6 hours, 4 times a day. 2. Methotrexate-polyinate rescue therapy: Starting 3 hours after the end of methotrexate administration, administer 15 mg as a polyinate intravenously every 3 hours for 9 doses, then administer intravenously or intramuscularly every 6 hours for 8 doses thereafter. 3. In metastatic colorectal cancer with 5-Fluorouracil (5-F

Precautions

This medication is not suitable for treating certain types of anemia caused by vitamin B12 deficiency, and caution is needed as blood status may improve even if neurological symptoms persist. The injection should be carefully administered by opening the glass ampoule to avoid glass fragments, especially when administering to children or the elderly. Pregnant or breastfeeding women should not use this medication, and it should also be avoided when combined with certain drugs. When using this medication, it may cause allergic reactions, injection site pain, fever, or neuropsychiatric symptoms, so any unusual symptoms should be reported to medical personnel immediately. This medication should only be used under the direction of a specialized doctor, and regular blood tests should be conducted to monitor treatment effectiveness and manage side effects. In particular, if kidney function is impaired or if there is fluid overload in the body, drug elimination may be delayed, requiring dosage adjustments. This medication may reduce potency or increase side effects when used with certain chemotherapy agents, thus caution is needed for combination therapy. Elderly patients or those with low physical condition are at higher risk for gastrointestinal side effects, so they should be administered with even more caution. This medication should not be administered intrathecally, and since it contains calcium, the infusion rate should be adjusted during intravenous administration. Store this medication out of reach of children and seal it in its original container to maintain drug safety and quality.

Side effects

Urticaria, anaphylactic reactions

Alternatives / Same-ingredient medications

• Perbon Injection (Polynate Calcium)

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• Pervon Injection 15 mg (Polynate Calcium)

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• 

  Pervon Tablet (Polynate Calcium)

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• Pfizer Like Cobolamin Injection 15 mg (Polynate Calcium)

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