Pervon Injection 15 mg (Polynate Calcium)

Key information summary

Efficacy & effects

This drug reduces the toxicity that can occur with the use of folic acid metabolic antagonists, thereby alleviating the burden on patients. Additionally, it helps enhance therapeutic effects when used in conjunction with 5-Fluorouracil (5-FU) in the treatment of advanced colorectal cancer. These effects can be expected in both the injectable and tablet forms. Therefore, this drug plays an important role in reducing side effects and improving therapeutic efficacy during cancer treatment.

Dosage

Injectable preparation 1. Methotrexate conventional therapy: In cases of adverse reactions from methotrexate, administer 6-12mg of the polyglutamate intramuscularly every 6 hours for 4 times a day. In the case of methotrexate overdose, administer the same amount of polyglutamate. 2. Methotrexate-polyglutamate rescue therapy: From 3 hours after the cessation of methotrexate administration, administer 15mg intravenously every 3 hours for 9 doses, followed by 6 hours.

Precautions

This drug is not suitable for the treatment of malignant anemia or megaloblastic anemia caused by vitamin B12 deficiency. During the progression of neurological symptoms, while blood conditions may improve, neurological symptoms may continue to worsen, so caution is advised. For the injectable form, care should be taken to prevent glass fragments from entering while opening the ampoule, especially when used in children or the elderly. Women who are pregnant or breastfeeding should avoid the drug in certain situations and should consider it carefully even if necessary. This drug can cause allergic reactions such as hives or anaphylaxis, so if unusual symptoms appear, consult a healthcare professional immediately. There may be pain at the injection site or vascular pain, and symptoms such as fever or central nervous system symptoms (paralysis, excitement, depression, etc.) may also occur. When used with other anticancer drugs, side effects such as diarrhea, skin reactions, and mucositis may occur, so regular examinations are necessary. This drug should be used under the direction of a specialist with experience in cancer treatment, and frequent blood tests are required to manage therapeutic effect and side effects. Particularly in cases of poor kidney function or abnormal hydration status, drug excretion may be delayed, requiring dosage adjustments. This drug may interact with certain anticancer agents, reducing effectiveness or increasing side effects, so it's crucial to inform about any concurrently taken medications. Elderly patients should be cautious as they may have a higher risk of gastrointestinal side effects, and generally, increasing age should be considered for declining physical function. This drug should not be administered intrathecally, and when given intravenously, the infusion rate should be adjusted due to calcium content. The drug should be stored out of reach of children and kept sealed in its original container for safety.

Side effects

Hives, anaphylactic reactions

Alternatives / Same-ingredient medications

• Perbon Injection (Polynate Calcium)

  Same ingredient
• 

  Pervon Tablet (Polynate Calcium)

  Same ingredient
• Pervon Injection 30 mg (Polynate Calcium)

  Same ingredient
• Pfizer Like Cobolamin Injection 15 mg (Polynate Calcium)

  Same ingredient

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