Pervon Tablet (Polynate Calcium)

Key information summary

Efficacy & effects

This injection helps reduce the toxicity of antifolates and is used in combination with 5-Fluorouracil (5-FU) to enhance treatment effectiveness for advanced colon cancer. Additionally, it is used in tablet form to alleviate the toxicity of antifolates. This medication plays a critical role in mitigating side effects and enhancing treatment effectiveness, particularly during cancer therapy. Therefore, this injection is used to reduce antifolate-related toxicity and treat colon cancer.

Dosage

1. Methotrexate standard therapy: Administer 6-12 mg as a polyglutamate by intramuscular injection every 6 hours for a total of 4 doses per day. 2. Methotrexate-polyglutamate rescue therapy: Administer 15 mg as a polyglutamate by intravenous injection every 3 hours starting 3 hours after the end of methotrexate infusion, followed by 8 doses of intravenous or intramuscular injection every 6 hours. 3. In advanced colon cancer with 5-Fluorouracil (5-F

Precautions

This medication is not suitable for the treatment of pernicious anemia or megaloblastic anemia caused by vitamin B12 deficiency. Even if neurological symptoms continue to progress, be cautious as blood conditions may improve. For the injection, be careful when opening the ampule as glass fragments may get mixed in, particularly when administering to children or the elderly, extra caution is required. It is advisable not to administer this drug to pregnant or breastfeeding women, especially in conjunction with 5-FU. If there is a possibility of pregnancy or in breastfeeding patients, careful administration is necessary. When administering this medication, be vigilant for allergic reactions such as hives or anaphylaxis. Pain at the injection site or temporary discomfort may occur, and rarely fever or central nervous system symptoms (such as paralysis, agitation, depression) may appear. When used with 5-FU, side effects such as diarrhea, skin reactions, and stomatitis may occur, and if symptoms are severe, adjustment of the 5-FU dosage may be necessary. This medication must be used under the direction of a physician experienced in chemotherapy, and monitoring of blood drug concentration is required to enhance treatment efficacy. In cases of poor kidney function or abnormal fluid retention, high doses may be administered intravenously. This medication acts in the body through the same pathways as methotrexate, thus if there is resistance to methotrexate, there may also be resistance to this medication. Patients who are vomiting or poorly absorbing medications are better treated with injection rather than orally. In patients with central nervous system tumors, repeated dosing can cause drug accumulation, thereby reduce anticancer effectiveness, so overdose should be avoided. This medication is not used for treating macrocytosis due to specific DNA synthesis inhibitors. Additionally, this medication is ineffective against certain side effects like kidney toxicity from methotrexate. It may affect liver metabolism and lower the blood concentration of certain anticonvulsants, so patients at risk of seizures require monitoring and dosage adjustment. When used in combination with 5-FU, caution is advised as the effects and side effects of 5-FU may be increased. When given together with the anticancer agents methotrexate or pyramethamine, this medication may reduce or eliminate their anticancer effects. When administered to pregnant women, the potential risks to the fetus and the benefits of this medication should be carefully considered, and breastfeeding women should be cautious as the drug may be excreted in breast milk. Elderly patients are at increased risk of gastrointestinal side effects, so careful observation is necessary. This medication is contraindicated for epidural administration, and when given intravenously, care should be taken not to exceed the calcium content limits per minute.

Side effects

Hives, anaphylactic reactions

Alternatives / Same-ingredient medications

• Perbon Injection (Polynate Calcium)

  Same ingredient
• Pervon Injection 15 mg (Polynate Calcium)

  Same ingredient
• Pervon Injection 30 mg (Polynate Calcium)

  Same ingredient
• Pfizer Like Cobolamin Injection 15 mg (Polynate Calcium)

  Same ingredient

Related searches