Yuhan Methotrexate Injection 25 mg/mL

Key information summary

Efficacy & effects

This medication is used to treat certain blood cancers such as leukemia. It also helps relieve symptoms of trophoblastic diseases (choriocarcinoma, destructive hydatidiform mole, hydatidiform mole). It can improve joint inflammation in patients with rheumatoid arthritis. In injectable form, it is widely used for treating various cancers such as acute leukemia, non-Hodgkin lymphoma, and sarcomas, as well as solid tumors like breast cancer and lung cancer. Additionally, it is utilized for treating severe refractory psoriasis that does not respond to other drugs. In summary, this medication is effective in improving symptoms of some chronic inflammatory diseases alongside cancer treatment.

Dosage

Leukemia: Methotrexate at 5-10 mg daily for 3-6 days a week orally. Trophoblastic disease: 10-30 mg daily orally. Administer in cycles of 5 days with a 7-12 day drug-free period before repeating. Rheumatoid arthritis: A test dose of 5-10 mg orally should be administered 1 week prior to treatment. Either 7.5-20 mg orally once a week or 2.5 mg in three doses at 12-hour intervals.

Precautions

This medication should be administered once a week for the treatment of rheumatoid arthritis or psoriasis. Serious side effects may occur if the dosage regimen is not followed properly. Combination with certain other chemotherapeutic agents is dangerous and should be administered under strict medical supervision, particularly when used with proton pump inhibitors, as toxicity may increase due to elevated blood concentrations. Patients with impaired kidney or liver function, blood disorders, pregnant women or those who may become pregnant, and nursing mothers should not use this medication. Patients with gastrointestinal diseases such as diarrhea, stomatitis, gastric ulcers, or weakened bone marrow function, patients with infections, children, and the elderly should use this medication carefully. This medication can cause various serious side effects, including shock, severe enteritis, pneumonia, hepatitis, renal failure, blood abnormalities, skin reactions, and infections, and should consult a doctor immediately if symptoms occur. This medication has immunosuppressive effects that may reduce vaccine efficacy and could affect blood test results, so regular testing is necessary. Use during pregnancy poses a risk of severe malformations or miscarriage, so pregnancy must be avoided, and men should refrain from planning a pregnancy during treatment and for six months afterward. This medication has many interactions with other drugs, so caution is needed when used in combination, especially with drugs that impair renal excretion, as toxicity may increase, necessitating consultation with a physician. In case of overdose, an antidote should be administered immediately, and appropriate measures should be taken; caution is also necessary in administration and storage. This medication should be kept out of the reach of children and should not be transferred to other containers.

Side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, paleness, severe rash with high fever, blisters, pain in oral/ocular mucosa, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities with cough and fever, jaundice (yellowing of skin or eyes), profound fatigue, sudden and severe headache, lightning headache, seizures, confusion of consciousness, visual disturbances, paralysis, urination

Alternatives / Same-ingredient medications

• MTX Injection (Methotrexate)

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• 

  Yuhan Methotrexate Tablets

  Same ingredient
• Pfizer Methotrexate Injection 5 g

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• Pfizer Methotrexate Injection 1 g

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