Biramid Capsule 100 mg (Ribavirin)

Adult dose

(Capsules, syrup) 1. Adults: Administer orally twice daily, adjusting the dose according to body weight. 1) Less than 65 kg: 800 mg per day (400 mg in the morning, 400 mg in the evening) 2) 65∼85 kg: 1000 mg per day (400 mg in the morning, 600 mg in the evening) 3) More than 85 kg: 1200 mg per day (600 mg in the morning, 600 mg in the evening) 2. Reduce the dose to 600 mg per day in patients with a hemoglobin level below 10 g/dL, and discontinue treatment in patients with a level below 8.5 g/dL. 3. In patients with a history of stable cardiovascular disease, if the hemoglobin level decreases by 2 g/dL or more within 4 weeks at any time during treatment, reduce the dose to 600 mg per day; discontinue treatment if the level remains below 12 g/dL after 4 weeks of taking the reduced dose. 4. Do not administer to patients with a creatinine clearance below 50 mL per minute. (Inhalation formulation) Administer using an aerosol generator continuously for 12～18 hours per day for 3～7 days. The appropriate solution concentration is 20 mg/mL; when administered for an average of 12 hours, the ribavirin concentration in the air reaches approximately 190 ㎍/Lr (0.19 mg/mL). Treatment should be started as soon as possible, within 3 days of lower respiratory tract infection caused by RSV. Prompt administration is necessary to effectively treat severe lower respiratory tract infection.

Child dose

Infants who are not receiving mechanical ventilation should receive the medication through an oxygen hood. If an oxygen hood is unavailable, it may be administered through a mask or oxygen tent. However, if the volume or concentration range of the oxygen tent is large, the drug delivery kinetics may change.

This medication should never be administered to pregnant women or women who could become pregnant, as well as their partners. It may cause serious malformations or fetal toxicity. It should also not be used in patients with unstable heart disease, as it can induce hemolytic anemia, which may worsen existing heart disease or lead to serious issues such as myocardial infarction. Patients with hypersensitivity, autoimmune hepatitis, severe liver or kidney dysfunction, hemoglobinopathy, and children or adolescents with severe mental disorders should also not be treated with this medication. Patients with a history of anemia or mental disorders, those with a history of gout, and elderly patients should use this medication cautiously, including blood tests and monitoring of mental status during treatment. While taking this medication, symptoms such as headaches, fatigue, depression, insomnia, shortness of breath, and visual disturbances may occur, so if any of these symptoms arise, consultation with a physician is required. Women who may become pregnant must ensure effective contraception during and for a period after treatment, and male patients must also ensure thorough contraception with their partners during and for a period after treatment. Women who are breastfeeding must discontinue breastfeeding while taking this medication, as it can be transmitted in breast milk and harm the infant. This medication may interact with certain drugs, so if you are taking other medications, it is important to inform your doctor or pharmacist. There is no specific antidote for overdose, and treatment should be based on symptoms, therefore care must be taken to avoid overdose. Lastly, the safety and efficacy of this medication in children under 18 years of age have not been sufficiently established, so it should be used cautiously in pediatric patients.

• Hemolytic anemia
• anemia
• aplastic anemia
• heart and lung diseases
• insomnia
• depression
• irritability
• suicidal behavior
• hearing impairment
• dizziness

This medication may be sensitive to air and moisture, so it should be stored in a tightly sealed container at room temperature. Proper storage will help maintain the effectiveness of the medication for a longer period.

Appearance

Soft gelatin capsules with an upper light blue and lower white color containing white powder

Package unit

30 capsules/bottle, 100 capsules/bottle