MTX Injection (Methotrexate)

Key information summary

Efficacy & effects

This medication in tablet form is used to treat leukemia, rheumatoid arthritis, and severe psoriasis that does not respond to other medications. It also helps alleviate subjective and objective symptoms caused by trophoblastic disease. The injectable form is effective in treating various cancer conditions such as acute leukemia, non-Hodgkin lymphoma, sarcoma, as well as solid tumors like breast cancer, lung cancer, head and neck cancer, and bladder cancer, and it contributes to the alleviation of symptoms in patients with severe psoriasis that does not respond to other medications. This drug plays an important role in the treatment of various cancers and refractory psoriasis.

Dosage

1. Leukemia Adults should be administered 5 to 10 mg of methotrexate once daily for 3 to 6 days per week. 2. Trophoblastic disease 10 to 30 mg should be taken orally once daily for a period of 5 days, followed by a 7 to 12-day drug withdrawal period before repeating the cycle. 3. Rheumatoid arthritis Before treatment, a test dose of 5 to 10 mg should be administered orally once to assess for specific adverse reactions in sensitive individuals. Administer once a week for 7.

Precautions

This medication should only be taken once a week for the treatment of rheumatoid arthritis or psoriasis, and it is important to follow the dosage instructions carefully as serious side effects can occur if not adhered to. Co-administration with certain chemotherapy agents can be risky, so it must be done under the supervision of a physician. When used alongside proton pump inhibitors, there is a risk of increased blood concentration of this drug, leading to toxicity; therefore, caution is required. Patients who have had an allergic reaction to this medication, those with impaired kidney or liver function, certain blood disorders or immunodeficiencies, as well as pregnant or nursing women should not use this medication. Patients experiencing diarrhea, stomatitis, gastric ulcers, infections, etc., should use this medication with caution, as should children and the elderly. This medication can cause serious side effects, including shock, gastrointestinal bleeding, pneumonia, neurological disorders, reproductive issues, blood disorders, liver damage, kidney damage, and skin reactions; if symptoms arise, immediate consultation with healthcare professionals is necessary. Long-term use requires frequent monitoring of bone marrow, liver, and kidney function, and attention should be paid to the risk of infections or bleeding. Women who are pregnant or may become pregnant should not take this medication, and men should avoid conception during and for a specified period after treatment. This drug interacts with many medications, so it is essential to consult with healthcare providers regarding any concurrent medications, especially those that interfere with renal excretion, as these greatly increase the risk of side effects. In case of overdose, immediate detoxification treatment is required; this drug is not removed by hemodialysis or peritoneal dialysis, so specialized treatment is needed. When storing, keep it out of reach of children and do not transfer it to another container.

Side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash accompanied by high fever, blisters, skin peeling, mucosal pain in the mouth/eyes, shortness of breath or difficulty breathing, asthma attacks, breathing abnormalities accompanied by cough and fever, jaundice (yellowing of the skin or eyes), extreme lethargy, sudden and very severe headache, lightning headache, seizures, altered consciousness, visual disturbances, paralysis, weakness

Alternatives / Same-ingredient medications

• 

  Yuhan Methotrexate Tablets

  Same ingredient
• Yuhan Methotrexate Injection 25 mg/mL

  Same ingredient
• Pfizer Methotrexate Injection 5 g

  Same ingredient
• Pfizer Methotrexate Injection 1 g

  Same ingredient

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