Cignatin Tablet (Cimetidine)

Adult dose

Adults: As cimetidine, 400 mg orally 2 times a day (morning and at bedtime) or 800 mg once a day (at bedtime). Additionally, 300 mg orally 4 times a day (after meals and at bedtime) may be given. The dose can be increased up to 1.6 g per day (400 mg 4 times a day after meals and at bedtime). For acute gastritis or acute exacerbations of chronic gastritis, 200 mg orally 2 times a day or 400 mg once a day may be administered.

Child dose

Children: Administer 20 to 40 mg per kg of body weight per day, divided into oral doses.

This medication contains the ingredient cimetidine and should not be administered to certain patients. For example, patients who are allergic to this medication or cimetidine or have experienced hypersensitivity, patients currently taking dofetilide, and patients with lactose intolerance or specific genetic metabolic disorders may be at risk when using this medication. Patients with impaired kidney or liver function, those with a history of drug allergies, the elderly, children under 19 years of age, and patients undergoing dialysis must exercise extra caution when using this medication and may require dosage adjustment or changes in dosing intervals. This medication can affect various organs such as the blood, liver, and kidneys, and symptoms like leukopenia, liver function abnormalities, renal impairment, allergic reactions, gastrointestinal symptoms, neurological symptoms, and skin reactions may appear, so if abnormal symptoms are detected, immediate consultation with a healthcare provider is necessary. Additionally, long-term or high-dose use of this medication may conceal symptoms of gastric cancer, so it is recommended to confirm the presence of malignant diseases prior to use. Patients with Helicobacter pylori infection should undergo bacterial eradication therapy concurrently. This medication can interact with several other medications, therefore, when taken with warfarin, midazolam, diazepam, beta-blockers, antidepressants, antibiotics, antifungals, and antidiabetic medications, dosage adjustments or discontinuation may be necessary. Pregnant or breastfeeding women should only use this medication when the therapeutic benefits outweigh the risks, and for breastfeeding mothers, it is recommended to discontinue breastfeeding while using this medication. In cases of overdose, serious side effects such as respiratory depression may occur, requiring immediate emergency treatment, and it should be stored out of reach of children to prevent accidents. Finally, elderly patients or those with impaired kidney function may experience delayed excretion of this medication, so dosage reduction or increased dosing intervals should be considered.

Serious side effects

• Leukopenia
• neutropenia
• agranulocytosis
• thrombocytopenia
• pancytopenia
• aplastic anemia
• immune hemolytic anemia
• jaundice
• acute renal failure
• renal dysfunction

Mild side effects

• General malaise
• weakness
• subcutaneous bleeding
• mucosal bleeding
• fever
• elevated AST
• ALT
• hepatitis
• interstitial seizures
• urinary retention

This medication should be stored in a tightly closed container to prevent exposure to air or moisture. Additionally, it is advisable to keep it away from direct sunlight and store it at normal room temperature.

Appearance

This medication is a white, round, film-coated tablet.

Package unit

1000 tablets/bottle