Dulacane Syrup (Lactulose Concentrate)

Key information summary

Efficacy & effects

Chronic portal-systemic encephalopathy, specifically hepatic encephalopathy in chronic PSE, is a condition that can lead to impaired brain function. This medicine is used for the treatment and prevention of hepatic encephalopathy. Patients can expect improvement in liver function and prevention of exacerbation of brain symptoms through this medication. Continuous treatment and management can help alleviate symptoms and positively impact the quality of life. Therefore, this medication is used for the prevention and treatment of hepatic encephalopathy in patients with chronic portal-systemic encephalopathy.

Dosage

For hepatic encephalopathy in chronic portal-systemic encephalopathy: - Initial dose: 30 to 50mL orally, three times a day. - Maintenance dose: Adjusted according to individual needs to avoid having more than 2 to 3 bowel movements per day. - Minimum dose: 25mL per day. Prevention of hepatic encephalopathy: - Initial dose: 25mL orally, three times a day. - Maintenance dose: Adjusted according to individual needs to avoid having more than 2 to 3 bowel movements per day.

Precautions

This medication should not be used in patients with inflammatory bowel disease, gastrointestinal obstruction, or gastrointestinal perforation, or in those at risk of these conditions. Patients with unexplained abdominal pain, those on a galactose-free diet, and those with hypersensitivity to this medication or its components should also avoid use. Additionally, since it contains lactose, caution is necessary for patients with galactose intolerance, lactase deficiency, or glucose-galactose malabsorption. Caution should be exercised when administering this medication to diabetic patients considering the sugar content, as well as to those with fructose intolerance or fluid and electrolyte imbalances. Patients with acute gastritis, infants and children, and the elderly also require careful administration. Initial dosing may cause abdominal bloating, but it usually subsides within a few days. In cases of overdose, abdominal pain and diarrhea may occur, requiring dosage adjustment, and prolonged high-dose use may lead to electrolyte imbalance. Long-term or excessive use may lead to dependence of bowel reflex function on the medication, requiring caution. During treatment of portal-systemic encephalopathy, it is advised not to use other laxatives simultaneously, and care should be taken in patients with liver diseases accompanied by electrolyte disorders. If loose stools or diarrhea occur, the dosage should be reduced or administration stopped. Patients taking this medication who are to undergo rectal or colonoscopy need thorough bowel preparation to avoid the risk of explosion due to hydrogen gas in the intestine. If abdominal pain of unknown origin occurs or if symptoms do not improve after administration, consult a physician immediately. This medication may interact with other drugs, so caution is needed when using it with acarbose, broad-spectrum antibiotics, diuretics, corticosteroids, amphotericin B, cardiac glycosides, and antacids. It can be safely used during pregnancy and breastfeeding. Elderly patients may have decreased physiological functions, so it is best to start with a small dose and monitor their condition, and regular serum electrolyte tests are recommended for long-term use. In children, long-term use may increase the risk of dental caries, so dental hygiene should be emphasized, and it should only be used when absolutely necessary due to the potential for impaired bowel reflex function. In cases of overdose, diarrhea and abdominal pain may occur, and when there is associated fluid loss, the dose should be reduced or administration stopped, and appropriate treatment such as electrolyte replenishment should be administered.

Side effects

Urticaria

Alternatives / Same-ingredient medications

• Dulacane E Syrup (Lactulose Concentrate)

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• Araxil Soft Syrup (Lactulose Concentrate)

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• Dolce Lac Syrup (Lactulose Concentrate)

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• Bebium Syrup (Lactulose Concentrate)

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