Zyloric Tablets (Allopurinol)

Adult dose

Adults Because a rapid reduction in blood uric acid levels may sometimes trigger an acute gout attack, start with a low dose (allopurinol 100 mg once daily), then increase by 100 mg each week until serum uric acid levels reach 7 mg/100 mL in men and postmenopausal women, or 6 mg/100 mL in premenopausal women. Do not exceed a maximum oral dose of 800 mg daily. In general, administer allopurinol orally after meals in 1～3 divided doses (not exceeding 300 mg per dose): 100 ∼ 300 mg daily for mild gout in adults, 300 ∼ 600 mg daily for moderately severe tophaceous gout, and 600 ∼ 800 mg daily for severe tophaceous gout. In patients with renal failure, reduce the dose according to creatinine clearance: 100 ～ 200 mg daily if creatinine clearance is 10 ～ 20 mL/min, and no more than 100 mg daily if it is below 10 mL/min. Administer in 1 ∼ 3 divided doses or at longer intervals. If plasma oxypurinol levels can be measured, adjust the dose to maintain plasma oxypurinol at 100 μmol/L(15.2 mg/L) or less.

Serious allergic reactions may occur during use of this medication, so if skin rashes or hypersensitivity symptoms appear, discontinue use immediately. Do not administer to children, nursing mothers, patients with allergies to this medication, or those with a history of severe adverse reactions. Patients with liver or kidney function problems, pregnant women, and the elderly should use this medication cautiously and require regular liver function tests and blood tests. This medication can cause various adverse reactions such as skin rashes, fever, and joint pain; consult a healthcare professional immediately if such symptoms occur. Caution is needed when driving or operating machinery as drowsiness or dizziness may occur. This medication can interact with other drugs, so inform your healthcare provider of any medications you are currently taking. Women who are pregnant or may become pregnant should be cautious when using this medication, and nursing mothers should avoid its use. Safety in children has not been established, and it should not be used except in special cases. Elderly patients may require dose adjustment due to decreased kidney function leading to increased drug concentration. It is recommended to maintain adequate hydration during treatment to increase urine output and alkalinize the urine. Store out of reach of children, and keep the medication in its original container to prevent deterioration in quality. Patients with specific genetic markers have a higher risk of serious skin reactions from this medication, so genetic testing before treatment may be considered. If serious skin reactions or hypersensitivity reactions occur during the use of this medication, discontinue use immediately and consult a healthcare professional.

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis (Lyell's Syndrome), Exfoliative Dermatitis, Hypersensitivity Vasculitis, Eosinophilia, Epidermal Peeling, Fever, Lymphadenopathy, Arthralgia, Hepatitis, Renal Dysfunction, Convulsions, Shock, Anaphylactic-like Symptoms, Aplastic Anemia, Pancytopenia, Agranulocytosis, Hepatic Dysfunction, Jaundice, Renal Failure, Worsening of Renal Failure, Interstitial Nephritis, Interstitial Pneumonia, Myalgia, Asthenia, Increased Creatine Kinase, Elevated Myoglobin in Blood and Urine, Stomatitis, Diarrhea, Convulsions, Anorexia, Abdominal Discomfort, Steatorrhea, Hematemesis, Renal Dysfunction, Taste Disorder, Visual Impairment, Peripheral Neuropathy, Peripheral Neuritis, Headache, Ataxia, Leukopenia, Thrombocytopenia, Hypoplatelet Count, Vascular Immune-associated Lymphoproliferative Disorder, Rash, Vasculitis, Lymphadenitis, Pseudolymphoma, Hepatosplenomegaly, Abnormal Liver Function Tests, Cholestatic Liver Disease, Itching, Cataract, Swelling, Generalized Malaise, Gynecomastia, Dizziness, Hyperlipidemia, Carbuncle, Angina, Hypertension, Bradycardia, Uremia, Hematuria, Angioedema, Hair Loss, Increased Thyroid Stimulating Hormone

This medication should be stored in a tightly sealed container to prevent air or moisture ingress. This helps maintain the effectiveness of the drug and prevents degradation.

Appearance

White round tablet

Package unit

30 tablets/bottle, 100 tablets/bottle