Sitagliptin/Metformin Tablets 50/1000 mg

Adult dose

This medication is typically taken twice a day with food, gradually increasing the dosage to reduce gastrointestinal side effects caused by metformin. The initial dosage depends on the patient's current therapy. 1. Patients not treated with metformin: Take one tablet of this medication 50/500 mg twice a day, and it can be increased to 50/1000 mg. 2. Patients currently treated with metformin:

This medication contains both sitagliptin and metformin and is used in diabetes treatment. First, a serious allergic reaction may occur while taking this medication, so if symptoms such as skin rash, difficulty breathing, or swelling of the face or neck appear, you must immediately discontinue use and consult a physician. Second, acute pancreatitis may occur, so if symptoms such as abdominal pain, nausea, vomiting, or fever arise, you should notify healthcare personnel immediately. Third, metformin may occasionally cause a serious metabolic disorder called lactic acidosis, so if experiencing sudden difficulty breathing, muscle pain, fatigue, or abdominal pain, you must immediately stop taking the medication and go to the hospital. Fourth, this medication should not be taken when kidney function is poor, and regular kidney function tests must be performed. Fifth, patients with certain conditions, such as severe infections, dehydration, heart failure, liver dysfunction, or women who are pregnant or breastfeeding, should not take this medication. Sixth, regular meals and appropriate exercise should be maintained while taking this medication, and care should be taken as hypoglycemia may occur. Seventh, the risk of hypoglycemia may increase when taken with other blood glucose-lowering agents or insulin, so medication dosage should be adjusted according to a physician's instructions. Eighth, if surgery or contrast-enhanced tests are planned, consult your physician to possibly temporarily discontinue the medication. Ninth, excessive alcohol consumption should be avoided while taking this medication, especially as alcohol can increase the risk of lactic acidosis. Finally, regular blood tests and kidney function tests should be conducted while taking this medication to ensure safe treatment.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweat, pallor, anaphylaxis, Stevens-Johnson syndrome including exfoliative skin disease, severe rash with fever, blisters, skin peeling, oral/eye mucosal pain, acute pancreatitis, acute renal failure, severe swelling, swelling accompanied by increased blood pressure, severe allergic reactions, difficulty breathing, asthma attacks, liver abnormalities (jaundice), sudden and very severe headache.

Mild side effects

• Diarrhea
• upper respiratory tract infection
• headache
• nausea
• vomiting
• abdominal pain
• constipation
• nasopharyngitis
• muscle pain
• limb pain

This medication should be stored in a tightly sealed container to prevent air and moisture from entering. It is best to maintain a storage temperature between 1 and 30 degrees Celsius.

Appearance

Dark red oval film-coated tablets

Package unit

56 tablets/box[14 tablets/PTPx4], 30 tablets/bottle, 200 tablets/bottle