Entence Injection

Adult dosage

The dosage and infusion rate are determined based on the patient's ability to eliminate fat, nitrogen, and glucose metabolism capacity, and nutritional requirements. For children over 12 years and adults, the dosage is 13-31 mL/kg per day with an amino acid content of 0.85-2.0 g/kg, providing total calories of 12-28 kcal/kg. The infusion rate must not exceed 1.5 mL/kg per hour, and administration should be over 14-24 hours.

Children's dosage

Children aged 2-11 years have greater variability than adults, so the daily dosage is regularly adjusted up to 31 mL/kg. The maximum recommended infusion rate is 1.8 mL/kg per hour over 12-24 hours.

This drug must be used strictly according to a doctor's instructions, and if any symptoms of anaphylaxis reaction such as fever, chills, rash, or difficulty breathing occur during use, the administration must be stopped immediately. This drug should not be administered simultaneously with ceftriaxone via the same injection apparatus due to possible precipitation; therefore, the two drugs should not be given together, and the infusion line must be thoroughly washed before and after use. Caution is needed in premature or low-birth-weight infants as the lipid component of this medication may not be well eliminated from the body and could pose risks. This medication should not be administered to specific patient groups such as those with allergies to fish, eggs, soy, peanuts, severe liver, kidney, or blood coagulation disorders, those in acute shock, or uncontrolled hyperglycemia. Patients with conditions affecting fat metabolism such as renal failure, diabetes, or liver dysfunction require careful observation during administration. This medication may cause various adverse reactions involving the heart, respiratory system, gastrointestinal tract, and circulatory system; therefore, administration should be reduced or stopped if symptoms occur. During administration, regular monitoring of blood triglycerides, glucose, electrolytes, and liver enzyme levels is necessary to ensure no abnormalities, particularly in patients with hyperlipidemia, as there is a risk for fat overload syndrome. Due to a higher risk of infection with central venous infusion, strict aseptic techniques must be employed, and any possibility of deficiency due to increased excretion of trace elements during long-term administration must be considered. Safety has not been established for pregnant or lactating women; therefore, administration should be done cautiously and only when necessary. This drug is not recommended for children under 2 years of age as the amino acid composition is not suitable for their needs. The lipid components of this drug may affect certain clinical test results, so it is preferable to perform tests 5-6 hours after administration. In cases of overdose, the infusion rate should be slowed or stopped, and emergency measures should be taken if necessary; if hyperglycemia occurs, insulin administration or adjustment of the infusion rate may be necessary. Rapid and continuous infusion of this drug can be hazardous; therefore, whenever possible, a pump should be used for slow and steady infusion, and it should not be mixed with other medications.

Serious side effects

Hives, difficulty breathing, anaphylactic reaction (severe allergic reaction), jaundice, fat overload syndrome (including symptoms of liver and blood disorders), coma (serious neurological symptoms), pulmonary edema, congestive heart failure, severe edema, blood coagulation disorders, hemolysis, asthma attack, confusion, paralysis, significant swelling of the body, increased blood pressure, symptoms related to renal failure.

Mild side effects

Tachycardia, anorexia, nausea, vomiting, increased plasma enzyme levels, hypotension, hypertension, mild fever, chills, dizziness, headache, skin rash, flushing, warmth, cooling sensation, cyanosis, pallor, pain (in neck, back, bones, chest, waist), hyperglycemia.

This medication should be stored in a sealed container to prevent air or moisture intrusion. The storage temperature should be maintained at room temperature between 1°C and 25°C. This helps preserve the effectiveness of the medication for a longer period.

Appearance

This medication consists of a plastic container for infusion divided into three internal compartments, with an oxygen absorber placed in between. Each internal compartment contains an amino acid and electrolyte solution.

Package unit

506 milliliters/bag [×6 (A solution: 331 mL, B solution: 102 mL, C solution: 73 mL)], 1012 milliliters/bag [×4 (A solution: 662 mL, B solution: 204 mL, C solution: 146 mL)], 1518 milliliters/bag [×4 (A solution: 993 mL, B solution: 306 mL, C solution: 219 mL)], 2025 milliliters/bag [×4 (A solution: 1325 mL, B solution: 408 mL, C solution: 292 mL)]