Medication info
Nophen S Tablet

Nophen S Tablet

OTC medicationTablet경구
Ingredient · strength
Acetaminophen›500mg / 1 tabletAnhydrous Caffeine›65mg / 1 tablet
Manufacturer / importer
한국신텍스제약(주)
Appearance
White rectangular tablet
Packaging
10 tablets/Blister, 20 tablets/Box [(10 tablets/Blister x2)], 30 tablets/Box [(10 tablets/Blister x3)], 100 tablets/Box [(10 tablets/Blister x10)], 30 tablets/Bottle, 60 tablets/Bottle, 90 tablets/Bottle, 300 tablets/Bottle
Approval status
Active

MFDS item code 202203657 · Notified 2022.09.23

Summary

Main use
Effective for pain relief (such as headaches and toothaches) and reducing fever
Who takes it
Adults
Adult dose
For individuals aged 15 years and older: take up to 1 tablet twice daily and avoid taking it on an empty stomach. The dosage interval should be at least 6 hours apart.

Ingredients

Manufacturer
한국신텍스제약(주)

Efficacy & effects

Effective for pain relief (such as headaches and toothaches) and reducing fever

  • Headaches
  • toothaches
  • post-extraction pain
  • sore throat
  • ear pain
  • joint pain
  • neuralgia
  • back pain
  • muscle pain
  • shoulder pain
  • bruise pain
  • fracture pain
View approved original text

This medication is used to alleviate various types of pain such as headaches, toothaches, sore throat, as well as post-operative pain, joint pain, back pain, muscle pain, shoulder stiffness, pain from bruises, pain from fractures or sprains, and menstrual pain. Additionally, it helps reduce body temperature during chills or fever, providing fever-reducing effects. In summary, this medication reduces discomfort caused by various pains and fever, effectively improving the patient's symptoms.

How to take

Adult dose

For individuals aged 15 years and older: take up to 1 tablet twice daily and avoid taking it on an empty stomach. The dosage interval should be at least 6 hours apart.

Precautions

This medication contains acetaminophen, which may affect the liver; therefore, those who regularly consume more than three glasses of alcohol daily should consult a physician or pharmacist before use. To prevent liver damage, this medication should not be taken in doses exceeding 4,000mg per day, and it should not be used in combination with other medications containing acetaminophen. If any unusual reactions such as skin rashes or itching occur during use, discontinue immediately and consult a healthcare professional. Persons with a history of allergic reactions to this medication or its components, those who have experienced asthma, and infants under three months of age should not take this medication. Avoid concurrent use with other antipyretic analgesics, cold medications, or sedatives, and consult healthcare professionals about any current illnesses or medications before use. Particular caution is warranted for children, elderly patients, pregnant or breastfeeding women, and those with liver or kidney disorders. If symptoms like nausea, vomiting, dizziness, swelling, skin rash, or difficulty breathing occur, discontinue use immediately and consult a doctor. This medication should not be used in children under the age of two, and when administering to children, the proper dosage and administration under parental supervision must be followed. Adhere to the prescribed dosage and frequency, avoid long-term use, and refrain from alcohol consumption during treatment. Rarely, serious metabolic acidosis may occur when this medication is taken alongside the specific antibiotic flucloxacillin; thus, it should be used carefully under medical supervision. Finally, this medication should be stored out of reach of children, kept away from direct sunlight, and in a sealed container in a cool, dry place. Additionally, it should not be transferred to other containers to maintain quality.

Side effects and when to seek care immediately

Serious side effects

  • Hives, severe swelling (edema), chest tightness, cold sweat, pallor → severe allergic reaction
  • Severe rash accompanied by high fever, blisters, skin peeling, pain in mucous membranes of the mouth/eyes → severe skin reaction
  • Difficulty breathing, asthma attack → respiratory issues
  • Yellowing of the skin or eyes (jaundice), extreme lethargy → liver abnormalities (jaundice)

Mild side effects

Rash, redness, itching, nausea, vomiting, loss of appetite, constipation, dizziness, swelling, high anion gap metabolic acidosis (HAGMA)

Not everyone experiences these, and they can vary from person to person.

Interactions

Drug interactions

Do not take this medication with other antipyretic analgesics, cold medications, or sedatives. Persons taking diabetes medications, gout medications, arthritis medications, anticoagulants, steroids, or other drugs should consult a physician or pharmacist. Consult a physician or pharmacist if taking barbiturates or tricyclic antidepressants simultaneously.

Food interactions

Do not consume alcohol while taking this medication.

Storage

This medication should be stored in a sealed container to prevent air or moisture from entering, and it is best kept at room temperature between 1 and 30 degrees Celsius. Storing it this way helps maintain the medication's effectiveness and prevents deterioration.

Appearance and packaging

Appearance

White rectangular tablet

Package unit

10 tablets/Blister, 20 tablets/Box [(10 tablets/Blister x2)], 30 tablets/Box [(10 tablets/Blister x3)], 100 tablets/Box [(10 tablets/Blister x10)], 30 tablets/Bottle, 60 tablets/Bottle, 90 tablets/Bottle, 300 tablets/Bottle

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

  • QIt’s a headache medication, how many times a day can I take it?

    For those aged 15 years and older, the recommended dosage is one tablet up to twice a day, taken with at least a 6-hour interval between doses and avoiding taking it on an empty stomach. Do not drink alcohol during the course of treatment, and do not take it with other antipyretic analgesics or cold medications.

    Answers 1 · 2026.09.14

For anything that needs medical judgment, consult a doctor or pharmacist.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.