Topstatin 20mg (Rosuvastatin Calcium)

Adult dose

This medication can be administered at any time of the day, regardless of meals. The initial dose is 5mg taken once daily and can be adjusted to a maintenance dose as needed. The maintenance dose is generally 10mg once daily, adjusted according to LDL cholesterol levels and patient response at intervals of at least 4 weeks. The maximum dose is 20mg per day.

Child dose

The general dosage range for pediatric patients aged 10 to 17 years is 5mg to 20mg once daily. The dosage should be adjusted individually according to the treatment goal, with adjustments made at intervals of at least 4 weeks.

This medication should not be administered to certain patients. For instance, individuals with allergies to any of its components, patients with severe liver dysfunction, those with muscle disorders, patients with severe kidney impairment, and women who are pregnant or breastfeeding should not use this medication. This medication can affect liver health, therefore, patients with a history of liver disease or those who consume alcohol excessively should undergo regular liver function tests before and during treatment. If there are conditions such as hypothyroidism, treatment for that condition should be completed before starting this medication. Muscle-related adverse reactions may occur, so if symptoms such as muscle pain or weakness develop, they should immediately inform healthcare professionals. Particularly, if muscle enzyme levels are elevated, discontinuation of this medication may be required. This medication may raise blood sugar levels in some patients, so those at high risk for diabetes should consistently monitor their blood sugar. Interactions may occur when taken with other medications, therefore, patients taking other drugs should inform their healthcare provider and consult them. This is particularly important when taken with certain antiviral agents, immunosuppressants, antibiotics, or fibrate medications. Women who may become pregnant should use appropriate contraception while taking this medication and should not use it during pregnancy. Breastfeeding women should also avoid using this medication. In case of overdose, there is no specific antidote; therefore, treatment should be symptomatic, and liver and muscle function tests may be necessary. Patients may experience dizziness or headaches when taking this medication, so caution should be observed while driving or operating machinery. Finally, if skin rash or severe allergic reactions occur while taking this medication, they should immediately stop taking the drug and contact healthcare professionals.

Serious side effects

Allergic reactions including hives and angioedema, Stevens-Johnson syndrome, drug reaction with eosinophilia and systemic symptoms (DRESS), jaundice, hepatitis, severe allergic reactions, severe skin reactions, difficulty breathing, respiratory distress, severe muscle weakness, ophthalmoplegia, myopathy, rhabdomyolysis, acute kidney failure, oliguria, thrombocytopenia, increased serum creatinine, severe edema, severe liver damage, and hyperbilirubinemia.

Mild side effects

• Headache
• dizziness
• constipation
• nausea
• abdominal pain
• itching
• muscle pain
• weakness
• hematuria
• diarrhea

This medication should be stored in a tightly sealed container to protect it from air and moisture, and it is best kept at a temperature between 1 to 30 degrees Celsius at room temperature. Proper storage will help maintain the effect of the medicine for a longer period.

Appearance

Pink round film-coated tablet

Package unit

Blister - 28 tablets/box [(14 tablets/blister) X 2], Bottle - 30 tablets/bottle