Senevit Injection

Adult administration

Children over 11 years and adults: 1 vial per day via a separate route. Dissolve the powder gently by adding 5 mL of sterile water for injection or 5% dextrose injection or normal saline injection into the vial. The solution appears light orange after dissolution. After dissolving, administer slowly intravenously or mix with 5% dextrose injection or normal saline injection for administration via a drip over at least 10 minutes.

Child administration

Children over 11 years and adults: 1 vial per day via a separate route. Dissolve the powder gently by adding 5 mL of sterile water for injection or 5% dextrose injection or normal saline injection into the vial.

This medicine should not be administered more than 5,000 IU of vitamin A per day to women in the first 3 months of pregnancy or those who may become pregnant. This is a precaution to reduce the risk of congenital malformations. Individuals allergic to any ingredient of this medicine or soy and peanut proteins should not use it. Additionally, it should not be used in children under 11 years, patients with vitamin overdose, patients with severe hypercalcemia or hypercalciuria, and patients already taking vitamin A or retinoids. Caution should be exercised when administering this medicine to patients with liver dysfunction or cholestasis, those taking vitamins D or E, and patients with liver or kidney dysfunction. In such cases, regular monitoring of liver function and vitamin levels is essential. This medicine may cause serious allergic reactions such as rash, urticaria, or anaphylaxis, which means that administration should be halted immediately if any abnormal symptoms arise. Excessive intake of vitamins A, D, and E can produce toxicity; therefore, the total vitamin intake must be checked when administering alongside other vitamin supplements or sources of nutrition. The compatibility with other injectable drugs should be confirmed before mixing this medicine, and the solution should be checked for clarity and absence of precipitate before administration. During pregnancy, the dosage of vitamin A from this medicine should be limited to less than 5,000 IU per day; nursing women are advised against use as it may lead to excess vitamin transfer to newborns. Regular clinical tests, such as liver function tests and vitamin blood level tests, should be conducted during the administration of this medicine. Special caution should be taken when interpreting test results as biotin may affect the results of certain laboratory tests. In cases of overdose, administration should be halted immediately, calcium intake should be reduced, and symptoms should be alleviated by promoting diuresis and hydration.

Serious side effects

• Urticaria
• anaphylactic shock
• chest tightness
• difficulty breathing
• hepatic jaundice or cholestasis
• severe allergic reactions
• severe skin adverse reactions

Mild side effects

Elevated liver enzymes (AST, ALT, γ-GT, ALP), biliary system abnormalities, rash, erythema, chest discomfort, systemic hypersensitivity reactions, platelet function abnormalities, and blood coagulation abnormalities

This medicine is sensitive to light; therefore, it should be stored in a container that does not allow light in. Additionally, it is important to keep it in a cool place below 25 degrees Celsius to maintain its efficacy.

Appearance

A colorless and odorless freeze-dried powder in a brown glass vial

Package unit

10 vials/box