Prastan Tablet 20 mg (Pravastatin Sodium)

Adult dose

Before starting treatment, patients should initiate a low-cholesterol diet and continue this throughout treatment. The usual starting dose is 10 mg, 20 mg, or 40 mg once daily. The dosage may be increased to a maximum of 40 mg based on patient response. The maintenance dosage is 10-40 mg once daily. 1) In patients with a history of myocardial infarction or unstable angina, the treatment goal of 'reduction of risk for myocardial infarction, need for cardiovascular revascularization, ischemic stroke, and transient ischemic attack' can be achieved with pravastatin sodium at a dose of 40 mg/day. The effects of lower doses have not been studied. 2) For patients receiving immunosuppressants like cyclosporine: the initial dose is 5-10 mg, with careful consideration for dose increases. The maximum daily dose is 20 mg. However, for kidney transplant patients, do not exceed 10 mg per day.

This medication should not be used in certain patients. For example, it is contraindicated in patients who are allergic to this medication or have hypersensitivity, patients with active liver disease, pregnant or potentially pregnant women, nursing mothers, children, patients with severe liver or kidney dysfunction, patients with muscle disorders, and patients with impaired bile flow. Additionally, this medication contains lactose and should not be administered to patients with lactose intolerance or certain genetic metabolic disorders. Patients with severe liver or kidney diseases or a history of such conditions should use this drug cautiously, as there is an increased risk of muscle damage when combined with specific medications. Potential side effects during treatment may include skin rashes or allergic symptoms, gastrointestinal disturbances, liver function abnormalities, muscle pain or weakness, kidney dysfunction, headache, dizziness, insomnia, etc. Especially, muscle-related adverse reactions such as myopathy or rhabdomyolysis may occur, so the physician should be notified immediately if muscle pain or weakness worsens. This drug inhibits cholesterol synthesis to lower blood cholesterol levels, but it can be harmful to the fetus during pregnancy; hence, women who are pregnant or planning to become pregnant should not take it. Elderly patients may require dose adjustments due to decreased physiological function. This medication may interact with other drugs, so any other medications being taken must be disclosed to healthcare professionals. Prior to administration, necessary tests such as blood tests should confirm the diagnosis of hypercholesterolemia, and regular blood tests should be performed during treatment. In case of overdose, appropriate monitoring, including liver function tests, should be conducted immediately at a hospital. This medication should be stored in a safe place out of reach of children, and changes in storage containers can affect its quality, so it should be avoided. It is effective to take this medication once daily after dinner, and the timing of administration should be adjusted if taken with certain antacids or ion-exchange resins.

Serious side effects

Urticaria, angioedema, anaphylaxis, thrombocytopenia, leukopenia, hemolytic anemia, dermatomyositis, severe liver dysfunction (increased ALT, AST, ALP, LDH, γ-GTP, total bilirubin), liver abnormalities (including jaundice), severe edema, severe allergic reactions, rhabdomyolysis accompanied by acute renal failure, severe edema or urinary abnormalities, serious neurological symptoms (acute muscle weakness, ophthalmoplegia

Mild side effects

Rash, itching, diarrhea, nausea, vomiting, constipation, abdominal pain, dyspepsia, stomatitis, heartburn, abdominal distension, loss of appetite, hypotension, arthritis, arthralgia, muscle disorders, headache, dizziness, insomnia, peripheral neuropathy, depression, malaise, fatigue, sleep disturbances, memory impairment, forgetfulness, amnesia, confusion, increased uric acid levels, hematuria, hair loss, erectile dysfunction, various skin changes (nodules, depigmentation, skin and mucosal dryness,

This medication should be stored in a tightly sealed container to protect it from air and moisture. It is advisable to maintain storage temperatures between 1 and 30 degrees Celsius.

Appearance

Reddish oval tablet

Package unit

100 tablets/PTP (10 tablets/PTP*10), 100 tablets/bottle, 300 tablets/bottle, 30 tablets/bottle