UltraSol Injection

Adult dosage

For adults, administer intravenously as a drip infusion at a maximum dosage of 1 to 1.5 grams of total amino acids per kg of body weight per day. The infusion rate should preferably be approximately 10 grams of total amino acids over 60 minutes, with a principle of administering 30 to 40 drops per minute.

Children's dosage

In children, the dosage and infusion rate should be adjusted appropriately for administration.

This medication must be used strictly according to a physician's instructions. It should not be administered to patients with severe renal impairment, hyperazotemia, amino acid metabolism disorders other than liver failure, metabolic disorders that hinder nitrogen utilization, cachectic heart failure, pulmonary edema, oliguria or anuria, hypernatremia and hyperchloremia, or alkalosis. Additionally, use should be avoided in patients with atrioventricular block, myasthenia gravis, those with excessive fluid intake, and patients with myocardial infarction. Caution is required for patients with severe acidosis, congestive heart failure, severe heart failure, edema due to sodium retention, hyperkalemia, and renal impairment, and since sodium bisulfite is included, caution must be taken for the possibility of allergic reactions or asthma attacks related to sulfites. Rarely, hypersensitivity reactions such as skin rash may occur with this medication, and gastrointestinal symptoms like nausea, vomiting, chest discomfort, palpitations, rapid heartbeat, and elevated blood pressure may develop. Rapid massive administration can lead to acidosis, hence caution is required, and severe side effects such as chills, fever, headache, respiratory distress, and shock may occur. If magnesium is included, peripheral vasodilation may occur, as well as various metabolic complications such as metabolic acidosis, hypophosphatemia, alkalosis, hyperglycemia, diabetes, osmotic diuresis, and dehydration, rebound hypoglycemia, elevated liver enzymes, vitamin deficiencies and excesses, electrolyte imbalances, childhood hyperammonemia, elevated BUN, serum amino acid imbalances, metabolic alkalosis, and systemic azotemia. Patients with reduced liver or kidney function may have elevated blood urea nitrogen levels or develop serious symptoms such as amino acid imbalance, metabolic alkalosis, or coma, so caution is advised. Electrolyte imbalances in massive doses must be particularly monitored, and excess dosing can lead to metabolic alkalosis, therefore caution is needed. Patients with kidney disease, lung disease, and severe heart disease must take care to avoid fluid overload and diabetic patients should frequently check their blood sugar levels. Patients with hyponatremia, liver, and kidney function failure must closely monitor their dosage adjusted and manage their hydration and electrolyte status. There may also be interactions with other medications, so caution is advised, especially when used with tetracyclines, calcium salts, and vitamin B1. The safety for pregnant women has not been established, so it should only be used when the therapeutic benefits outweigh the risks. In children, the concentration of administration should be kept low, and levels of blood ammonia should be frequently monitored. The elderly should be cautious due to reduced physiological functions, slowing the rate of administration and reducing the dose as needed. During administration, attention should be paid to the electrolyte content, and rapid infusion should be avoided. The infusion should be warmed to body temperature and maintained in a sterile state, with thorough sterilization of injection equipment. If the solution is cloudy or discolored, do not use it, and it should be used within 24 hours without opening the packaging during storage. If there is leakage from the medication or any abnormalities with the packaging, it should be avoided.

Serious side effects

Hives, severe swelling (edema), difficulty breathing, respiratory distress, respiratory arrest, shock, bronchial spasm, asthma attacks, severe systemic edema (swelling) with elevated blood pressure, liver failure, kidney failure, symptoms related to liver dysfunction (jaundice), severe allergic reactions, serious neurological symptoms (loss of sensation, coma, etc.)

Mild side effects

• Nausea
• vomiting
• rash
• chest discomfort
• palpitations
• rapid heartbeat (tachycardia)
• elevated blood pressure
• headache
• chills
• fever

This medication should be stored in a tightly sealed container to prevent air and moisture from entering, and it is best to keep it at room temperature between 1 and 30 degrees Celsius. Storing it this way will help maintain the efficacy of the medication and prevent deterioration.

Appearance

An injection filled with a colorless to pale yellow solution in a colorless transparent glass or plastic container.

Package unit

250 mL/bottle